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  1. 5 hours ago · With a population of 278,349 according to the 2020 census, Buffalo is the second-most populous city in New York state and the 81st-most populous city in the U.S. Buffalo and the city of Niagara Falls together make up the two-county Buffalo–Niagara Falls metropolitan area, which had an estimated population of 1.2 million in 2020, making it the 49th-largest metro area in the U.S.