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Mar 5, 2024 · The antidote to acetaminophen overdose is N-acetylcysteine (NAC). It is most effective when given within eight hours of ingesting acetaminophen.
May 7, 2024 · It may occur following an acute ingestion or through repeated ingestions of supratherapeutic amounts. The management of the acetaminophen-poisoned patient may include stabilization, decontamination, and administration of acetylcysteine, a specific antidote.
In January 1985, the United States (US) Food and Drug Administration (FDA) approved the oral administration of acetylcysteine (N-acetylcys-teine, NAC) as an antidote for the treatment of acetaminophen overdose.
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Treatment |. More Information. (See also Overview of Poisoning.) Liver failure can follow. Most overdoses cause no immediate symptoms. If the overdose is very large, symptoms develop in 4 stages: In stage 1 (after several hours), the person may vomit but does not seem ill. Many people have no symptoms in stage 1.
Apr 19, 2022 · About one-third are hospitalized for treatment with the antidote, acetylcysteine, and 1%–2% die. 1 Most fatalities result from delayed presentation after deliberate overdose, or from excessive dosing for fever or pain over several days.
Jul 7, 2024 · Gastric lavage may be needed to clean out your stomach to get rid of the acetaminophen. Gastric lavage is also called having your stomach pumped. Antidote medicine may be given to stop the effect of the overdose. You may also be given medicine to slow the effects of acetaminophen.
For a single acute overdose with extended-relief acetaminophen (which has 2 peak serum levels about 4 hours apart), acetaminophen levels are measured ≥ 4 hours after ingestion and 4 hours later; if either level is above the Rumack-Matthew line of toxicity, treatment is required.
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