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- Indican is an indole produced when bacteria in the intestine act on the amino acid, tryptophan. Most indoles are excreted in the feces. The remainder is absorbed, metabolized by the liver, and excreted as indicanin the urine. Indican normally appears in urine only at low levels, since it’s not normally produced in the cells of your body.
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What is indican testing?
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How to detect Indican?
Indican is an indole produced when bacteria in the intestine act on the amino acid, tryptophan. Most indoles are excreted in the feces. The remainder is absorbed, metabolized by the liver, and excreted as indicanin the urine. Indican normally appears in urine only at low levels, since it’s not normally produced in the cells of your body.
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Indican is a colourless organic compound, soluble in water, naturally occurring in Indigofera plants. It is a precursor of indigo dye. [1] Chemical reactions. Indican is a glycoside. Common and significant reactions involving indican are as follows: The hydrolysis of indican yields β-D- glucose and indoxyl.
Indole that is absorbed from the small intestine is converted to indican (1H-indol-3-ol hydrogen sulfate ester) in the liver. Indican is conjugated with potassium sulfate or glucuronic acid. After reentering the general circulation, indican is then excreted by the kidneys, and the concentration of indican can be measured in the urine (Fig. 31.1).
- What Is Indican
- Diseases Associated with High Levels
- From The Blood Type Diet Book
Indican testing can be a useful tool for monitoring degeneration or improvement in digestive efficiency of your system in dealing with protein. Indican is formed by an abnormal metabolism of tryptophan. This is a by-product of putrefaction (protein degradation), usually in the intestine, but possibly in other locations as well. Putrefaction is the ...
Among the different conditions in which urinary indican is likely elevated are hypochlorhydria (low stomach acid production), inhibited peristaltic movement (the involuntary muscular “waves” that move food through your bowel), and poor production of digestive bile secretions from the gall bladder and liver. Elevated levels are rather rare in simple...
Dr. D’Adamo wrote about the Indican test in his New York Times Bestseller Eat Right For Your Type. To read another article written by Dr. D’Adamo, please click here. To schedule an appointment, please contact the front desk of the Personalized Natural Medicine Clinic, located in a beautiful Victorian house in the heart of Newtown, Connecticut.
Indican is a byproduct of tryptophan putrefaction by microbes in the gut. Accumulated levels of indican in the urine suggest higher levels of tryptophan putrefaction from gastrointestinal dysbiosis or malabsorption. Production of indican occurs when tryptophan creates indoles in the colon.
Indican is produced from tryptophan in a manner reminiscent of the production of p-cresol sulfate from tyrosine and phenylalanine. Gut bacteria convert tryptophan to indole, which is then oxidized to indoxyl and conjugated with sulfate in the liver.
Nov 14, 2018 · Indican is an indole produced when bacteria in the intestine act on the amino acid, tryptophan. Most indoles are excreted in the feces. The remainder is absorbed, metabolized by the liver, and excreted as indican in the urine.
