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  2. Dec 9, 2022 · This review provides a case-based discussion of the differential diagnosis of HES, including the classification by clinical HES subtype. Treatment options are reviewed, including novel eosinophil-targeted agents recently approved for the treatment of HES and/or other eosinophil-associated disorders.

  3. Jul 22, 2022 · The hypereosinophilic syndromes (HES) are a group of disorders marked by the sustained overproduction of eosinophils, in which eosinophilic infiltration and mediator release cause damage to multiple organs.

  4. Nov 30, 2018 · In 1975, Chusid et al 2 described 14 cases of “idiopathic” HES defined by the presence of an AEC ≥1500/μL for 6 months (or death before that time), the absence of a known secondary cause, and evidence of eosinophilic end organ manifestations.

    • Amy Klion
    • 2018
  5. Aug 27, 2015 · Hypereosinophilic syndromes (HESs) are a group of rare disorders characterized by peripheral blood eosinophilia of 1.5 × 10 9 /L or higher and evidence of end organ manifestations attributable to the eosinophilia and not otherwise explained in the clinical setting.

    • Amy D. Klion
    • 2009
  6. Hypereosinophilic syndrome (HES) is a group of rare hematologic disorders leading to eosinophil-driven tissue damage and dysfunction. Better understanding of HES variants may facilitate improved patient management.

  7. Hypereosinophilic syndrome is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. [5]

  8. Mar 14, 2022 · Hypereosinophilic syndrome (HES) is a rare condition caused by an overload of white blood cells called eosinophils. Eosinophils protect your body from parasitic infections and respond to allergens. Normally, eosinophils account for 5% to 7% of your white blood cells, or about 100 to 500 eosinophils per microliter of blood.

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