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1. • • The rewired circuit operates as a clock-like device, called a gene oscillator, that drives the cell to periodically switch between two detrimental “aged” states, avoiding prolonged commitment to either, and thereby slowing the cell’s degeneration.
     scitechdaily.com/turning-back-the-clock-genetic-engineers-rewire-cells-for-an-82-increase-in-lifespan/

     Turning Back the Clock: Genetic Engineers Rewire Cells for an ...

2. People also ask

   Can stem cells help detect epigenetic clocks?

   • Horvath speculates that changes affecting stem cells, which are present at low levels in adult tissues, might make a big contribution to the signals epigenetic clocks detect. And the field eagerly awaits the maturation of techniques that can measure the methylomes of individual cells.

   Turning back time with epigenetic clocks - Nature

   www.nature.com/articles/d41586-022-00077-8

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   Can stem cells revert back to a pluripotent state?

   • In 2020, his lab adapted a method previously developed to make differentiated cells revert back to a pluripotent stem-cell state. By introducing genes for certain transcription factors, his team hoped to partly reprogramme the cells.

   Turning back time with epigenetic clocks - Nature

   www.nature.com/articles/d41586-022-00077-8

   See all results for this question

   How do epigenetic clocks work?

   • Epigenetic clocks use algorithms to calculate biological age on the basis of a read-out of the extent to which dozens or even hundreds of sites across an individual’s genome are bound by methyl groups — a form of epigenetic modification.

   Turning back time with epigenetic clocks - Nature

   www.nature.com/articles/d41586-022-00077-8

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3. www.nature.com › articles › d43747/023/00126-9The quest to turn back the clock - Nature

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   Dec 1, 2023 · 01 December 2023. The quest to turn back the clock. Approaches to slow or reverse aging have gained momentum in recent years, but the field is still in its infancy with hurdles to overcome, as...

   • Author: Raveena Bhambra

4. hsci.harvard.edu › stem-cell-research-progressesStem cell research progresses by turning back the clock

   hsci.harvard.edu › stem-cell-research-progresses

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   The field of stem cell research passed a critical landmark last November with the discovery that one could “turn back the clock” on human skin cells, reverting them to a state resembling an embryonic stem cell.

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6. time.com › 6246864Scientist Discovers Aging Clock to Speed and Reverse Aging | TIME

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   Jan 12, 2023 · Using three of the four factors turned back the clock about 57%, enough to make the mice youthful again. “We’re not making stem cells, but turning back the clock so they can regain their ...

7. www.scientificamerican.com › article › is-agingTurning Back the Cellular Clock: A Farewell to Embryonic Stem ...

   www.scientificamerican.com › article › is-aging

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   Dec 1, 2008 · Shinya Yamanaka discovered how to revert adult cells to an embryonic state. These induced pluripotent stem cells might soon supplant their embryonic cousins in therapeutic promise

8. www.nature.com › articles › d41586/022/00077-8Turning back time with epigenetic clocks - Nature

   www.nature.com › articles › d41586/022/00077-8

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   Jan 19, 2022 · Molecular horology. The DNA methylation that underpins epigenetic clocks is a reversible process that is catalysed by enzymes. It involves the addition of a tag known as a methyl group to parts...

9. www.nature.com › articles › s41592/022/01531-1Reversing the clock on human somatic cells | Nature Methods

   www.nature.com › articles › s41592/022/01531-1

   Jun 10, 2022 · A chemical cocktail reprograms human somatic cells into pluripotent stem cells. Cellular reprogramming is the method by which lineage-committed cells can be reverted to cells with...

10. www.nytimes.com › aging-dna-epigenetics-cellsTurning Back the Clock on Aging Cells - The New York Times

    www.nytimes.com › aging-dna-epigenetics-cells

    Mar 24, 2020 · The Stanford team, led by Tapash Jay Sarkar, Dr. Thomas A. Rando and Vittorio Sebastiano, say their method, designed to reverse these errors and walk back the cells to their youthful state,...