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  1. Carisma is led by a seasoned management team with extensive cell therapy, oncology and drug development experience, as well as an unrelenting focus on patients. Everything we do is centered around igniting hope in patients living with cancer and other serious conditions.

  2. Carismas novel chimeric antigen receptor macrophage (CAR-Macrophage) and CAR-Monocyte technologies have the potential to transform the way cancer is treated. Our Technology. The leader in engineered macrophages. Engineered macrophages are key drivers of both innate and adaptive immune responses.

  3. Carismas Board of Directors has deep expertise in science, technology, drug development, finance, and strategy, positioning Carisma to be an industry leader in the development and commercialization of next generation cell therapies.

  4. Nov 24, 2021 · At present, the first-in-human CAR-M Phase I clinical trial is underway using Carisma Therapeutic’s lead product CT-0508 for treating HER2 overexpressing solid tumors (NCT04660929). Results from this Phase I trial and others will provide invaluable insights to guide the design of safe and effective CAR-M therapies.

    • 10.3389/fimmu.2021.783305
    • 2021
    • Front Immunol. 2021; 12: 783305.
  5. Oct 25, 2023 · Carisma is selecting participants who have tumors of any anatomical origin, but with the commonality of overexpressing the HER2 receptor on the cell surface, which is the target for our CAR-M. The Phase 1 clinical trial marks the first time that engineered macrophages are being studied in humans.

  6. Carisma Therapeutics Announces First Patient Dosed in Phase 1 Clinical Trial of CT-0525, a Novel HER2-Targeting CAR-Monocyte

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  8. Carisma Therapeutics Inc. is a clinical stage biopharmaceutical company focused on utilizing our proprietary macrophage and monocyte cell engineering platform to develop transformative...