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  1. andrewslab.caAndrews Lab

    David W. Andrews, Ph. D. Dr. David Andrews is director of and senior scientist in Biological Sciences at Sunnybrook Research Institute (SRI), Professor of Biochemistry and Medical Biophysics at University of Toronto and a Tier 1 Canada Research Chair.

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      Dr. David Andrews is director of and senior scientist in...

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      Publications - Andrews Lab

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      A new paper published in Molecular Cell by senior author Dr....

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  2. medbio.utoronto.ca › faculty › andrewsDavid Andrews | Medical Biophysics - University of Toronto

    • At A Glance
    • Short Bio
    • Research Synopsis
    • Recent Publications
    Cancer research: programmed cell death, apoptosis, Bcl-2 family proteins, drug development, and personalized medicine
    Membrane biogenesis research: protein-protein interactions, assembly of proteins into membranes, tail-anchored proteins
    Technology Development: New automated microscopes for Fluorescence Lifetime Imaging Microscopy (FLIM), Forster Resonance Energy Transfer (FRET) and hyperspectral imaging. New software for automated...
    Commercialization:Collaborations with multiple pharmaceutical companies and started two biotech spin-off companies

    See full list on medbio.utoronto.ca

    Dr. David Andrews is Director of and Senior Scientist in Biological Sciences at Sunnybrook Research Institute (SRI). He holds a Tier 1 Canada Research Chair in Membrane Biogenesis. His research comprises, the molecular mechanisms by which Bcl-2 family proteins regulate apoptosis, early stage drug discovery, high-content screening and development of...

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    Regulation of apoptosis by Bcl-2 family proteins. The Bcl-2 family proteins primarily responsible for drug responses (and the lack thereof) include: i) the anti-apoptotic proteins: Bcl-2, Bcl-XL and Mcl-1, ii) the pro-apoptotic executioner proteins Bax and Bak and iii) the pro-apoptotic regulator BH3-proteins Bid, Bim, Bad, Bik, Puma and Noxa. Our ...

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    Leber B, Kale J, Andrews DW. Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove. Cancer Discov. 2018 Dec;8(12):1511-1514.
    Liu Q, Osterlund EJ, Chi X, Pogmore J, Leber B, Andrews DW. Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2. Elife. 2019 Mar 12;8:e37689.
    Hickman KA, Hariharan S, De Melo J, Ylanko J, Lustig LC, Penn LZ, Andrews DW. Image-Based Analysis of Protein Stability. Cytometry A. 2020 Apr;97(4):363-377.
    Bogner C, Kale J, Pogmore J, Chi X, Shamas-Din A, Fradin C, Leber B, Andrews DW. Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax. Mol Cell. 2020 Feb...

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  3. biochemistry.utoronto.ca › person › david-w-andrewsBiochemistry, University of Toronto – David W. Andrews

    David W. Andrews. Professor. BSc, University of Ottawa, Canada, 1979. PhD, University of Toronto, Canada, 1985. Postdoc, University of California, San Francisco, USA, 1988.

    • david.andrews@sri.utoronto.ca
    • 416-480-6100, ext. 5120
    • Andrews Lab

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    • David ANDREWS | Ph.D. Department of Medical Biophysics, University of ...
    • David Andrews | Department of Statistical Sciences
    • Biochemistry, University of Toronto – David W. Andrews
    • DAVID ANDREWS Obituary (2018) - Whitby, ON - Toronto Star
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    • David Andrews is reportedly 'ready to go' for Bills game

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  5. www.statistics.utoronto.ca › david-andrewsDavid Andrews | Department of Statistical Sciences

    Areas of Interest. Statistical computing. Robust estimation. Graphical methods.

  6. www.utoronto.ca › news › david-andrews-leadingDavid Andrews, a leading statistician ... - University of Toronto

    Jun 14, 2023 · He has served as the network’s chief statistician for more than 100 elections. A former chair of the University of Toronto’s department of statistical sciences, Andrews has also made an immense impact in the field of statistics itself – notably statistical computing and graphics.

  7. www.statistics.utoronto.ca › news › david-andrewsDavid Andrews receives U of T honorary degree

    Feb 28, 2023 · We are excited to share the news that David Andrews, a U of T alumnus and professor emeritus in our department, will be awarded an honorary degree from the University of Toronto this spring. This prestigious award recognizes David's groundbreaking and transformative contributions to the field of statistical sciences, as well as his outstanding ...

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  9. andrewslab.ca › front-pageHome | Andrews Lab

    Professor, Department of Biochemistry, Univ. of Toronto Sunnybrook Research Institute, 2075 Bayview Avenue,M7-640, Toronto, ON M4N 3M5: Phone: 416-480-6100, ext. 5120