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    • Remote ischemic conditioning

      • Remote ischemic conditioning (RIC) is an emerging and promising approach to attenuate postoperative renal IRI. In this strategy, several cycles of intermittent nonlethal ischemia and reperfusion are applied to a remote organ or issue, which could render the kidney more resistant against subsequent lethal ischemia and reperfusion [ 8 – 10 ].
      journals.plos.org/plosone/article?id=10.1371/journal.pone.0170729
  1. May 3, 2024 · Remote ischemic conditioning (RIC) has the potential to benefit graft function following kidney transplantation by reducing ischemia-reperfusion injury; however, the current clinical evidence is inconclusive.

  2. Nov 2, 2020 · Remote ischaemic conditioning (RIC) is currently being explored as a non-invasive method to attenuate ischaemia/reperfusion injuries in organs. A randomised clinical study (CONTEXT) evaluated the effects of RIC compared to non-RIC controls in human kidney transplants. Methods.

    • Adam M. Thorne, Honglei Huang, Darragh P. O‘Brien, Marco Eijken, Marco Eijken, Nicoline Valentina Kr...
    • 10.1186/s12014-020-09301-x
    • 2020
    • Clin Proteomics. 2020; 17: 39.
  3. Apr 5, 2023 · Studies have shown that remote ischemic conditioning (RIC) can effectively attenuate ischemic-reperfusion injury in the heart and brain, but the effect on ischemic-reperfusion injury in patients with kidney transplantation or partial nephrectomy remains controversial.

    • 10.3389/fsurg.2023.1024650
    • 2023
    • Front Surg. 2023; 10: 1024650.
  4. Jan 27, 2017 · We conducted this meta-analysis of randomized controlled trials (RCTs) to investigate whether remote ischemic conditioning (RIC) could improve graft functions in kidney transplantation. Methods. PubMed, Web of Science, and Cochrane Library were comprehensively searched to identify all eligible studies by October 5, 2016.

    • Chang-Cheng Zhou, Yu-Zheng Ge, Wen-Tao Yao, Ran Wu, Hui Xin, Tian-Ze Lu, Ming-Hao Li, Kai-Wei Song, ...
    • 2017
  5. This large renal transplantation study including patients with a high risk of DGF shows that RIC performed during the transplant surgery to the recipients of deceased donor kidneys does not improve the time to graft recovery.

  6. Delayed graft function is a frequent complication following deceased donor renal transplantation, and is closely related to ischemia-reperfusion injury. Experimental and clinical studies have shown protection by remote ischemic conditioning (RIC).

  7. This brief commentary aims to discuss the effects of RIC on clinical outcomes and proinflammatory cytokines in patients undergoing kidney transplantation. Keywords: ischemia; ischemic preconditioning; kidney; remote ischemic preconditioning; renal transplant; reperfusion.

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