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1. hopkinscf.org › knowledge › cftrCFTR - Johns Hopkins Cystic Fibrosis Center

   hopkinscf.org › knowledge › cftr

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   The cystic fibrosis transmembrane conductance regulator (CFTR) is defective in cystic fibrosis (CF). This protein is a channel that sits on the surface of cells and transports chloride and other molecules, such as bicarbonate.

2. www.cff.org › research-clinical-trials › basics-cftrBasics of the CFTR Protein | Cystic Fibrosis Foundation

   www.cff.org › research-clinical-trials › basics-cftr

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   Cystic fibrosis occurs when the cystic fibrosis transmembrane conductance regulator (CFTR) protein is either not made correctly, or not made at all. By understanding how the protein is made, scientists have been able to develop treatments that target the protein and restore its function.

3. www.cff.org › managing-cf › cftr-modulator-therapiesCFTR Modulator Therapies | Cystic Fibrosis Foundation

   www.cff.org › managing-cf › cftr-modulator-therapies

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   The following video shows what it looks like when the CFTR protein functions normally in the lungs and what happens when the protein doesn't work. CFTR modulators have been approved by the U.S. Food and Drug Administration (FDA) for people with the specific CF mutations.

4. www.cff.org › intro-cf › cf-genetics-basicsCF Genetics: The Basics | Cystic Fibrosis Foundation

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   Cystic fibrosis is caused by mutations in the gene that produces the cystic fibrosis transmembrane conductance regulator (CFTR) protein. In people with CF, mutations in the CFTR gene can disrupt the normal production or functioning of the CFTR protein found in the cells of the lungs and other parts of the body.

5. www.biointeractive.org › classroom-resourcesCystic Fibrosis Mechanism and Treatment - HHMI BioInteractive

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   Apr 19, 2018 · Cystic fibrosis is an autosomal recessive disease caused by mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR is an ion channel protein that transports chloride ions across the membranes of cells that line airways, glands, and the digestive tract.

6. www.khanacademy.org › science › health-and-medicineWhat is cystic fibrosis? (video) | Khan Academy

   www.khanacademy.org › science › health-and-medicine

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   But for now, just think of cystic fibrosis or what we usually just say CF, as just a name for this disease and we'll find out step-by-step what it actually describes. First, cystic fibrosis is a genetic thing, so, it comes from our genes or is encoded in our DNA.

7. People also ask

   Can CFTR mutations cause cystic fibrosis?

   • A person must inherit two copies of the CFTR gene that contain mutations — one copy from each parent — to have cystic fibrosis. Cystic fibrosis is caused by mutations in the gene that produces the cystic fibrosis transmembrane conductance regulator (CFTR) protein.

   CF Genetics: The Basics | Cystic Fibrosis Foundation

   www.cff.org/intro-cf/cf-genetics-basics

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   What are cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies?

   • What Are They? Cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies are designed to correct the malfunctioning protein made by the CFTR gene. Because different mutations cause different defects in the protein, the medications that have been developed so far are effective only in people with specific mutations.

   CFTR Modulator Therapies | Cystic Fibrosis Foundation

   www.cff.org/managing-cf/cftr-modulator-therapies

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   What is a CFTR ion channel?

   • The cystic fibrosis transmembrane conductance regulator (CFTR) protein helps to maintain the balance of salt and water on many surfaces in the body, such as the surface of the lung. The CFTR protein is a particular type of protein called an ion channel. In the lung, the CFTR ion channel moves chloride ions from inside the cell to outside the cell.

   Basics of the CFTR Protein | Cystic Fibrosis Foundation

   www.cff.org/research-clinical-trials/basics-cftr-protein

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   What happens if a CFTR gene is mutated?

   • Mutations in the CFTR gene cause the CFTR protein to malfunction or not be made at all, leading to a buildup of thick mucus, which in turn leads to persistent lung infections, destruction of the pancreas, and complications in other organs. Cystic fibrosis is an example of a recessive disease.

   CF Genetics: The Basics | Cystic Fibrosis Foundation

   www.cff.org/intro-cf/cf-genetics-basics

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8. online-radio-canada.com › 680-newsCityNews 680 – CFTR (AM) - Toronto - listen live - Radio Online

   online-radio-canada.com › 680-news

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   CFTR CityNews 680 is a radio station that serves the Greater Toronto Area at 680 AM, broadcasts all-news format, also publishes current gas prices.