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1. academic.oup.com › database › articleFooDrugs: a comprehensive food–drug interactions database ...

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   Nov 9, 2023 · Food–drug interactions (FDIs) occur when a food item alters the pharmacokinetics or pharmacodynamics of a drug. FDIs can be clinically relevant, as they can hamper or enhance the therapeutic effects of a drug and impact both their efficacy and their safety.

2. www.ncbi.nlm.nih.gov › pmc › articlesFood Effects on Oral Drug Absorption: Application of ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Jul 17, 2020 · The consumption of food leads to physiological changes, including fluctuations in the gastric and intestinal pH, a delay in gastric emptying, an increased bile secretion, and an increased splanchnic and hepatic blood flow.

   • Author: Lisa Cheng, Harvey Wong
   • DOI: 10.3390/pharmaceutics12070672

   • Publish Year: 2020
   • Publication: Pharmaceutics. 2020 Jul; 12(7): 672.

3. bpspubs.onlinelibrary.wiley.com › doi › 10Food–drug interactions risk management: An emergent piece of ...

   bpspubs.onlinelibrary.wiley.com › doi › 10

   1 day ago · This is also true for food–drug interactions and significantly more complex due to different alimentary patterns and profiles. Moreover, ignoring the intake of potential foods/supplements that produce drug interactions among participants in clinical trials can result in considerable variability in the outcomes. 3

4. www.researchgate.net › publication › 341280885(PDF) Interactions between Common Foods and Drugs -A ...

   www.researchgate.net › publication › 341280885

   May 9, 2020 · The study analyzed that so many foods are having adverse effects on the human body while interacting or reacting with some medication. Foods and drugs both are mandatory, but the...

5. www.sciencedirect.com › science › articleAssessment of food effects during clinical development

   www.sciencedirect.com › science › article

   Mar 25, 2023 · 1. Introduction. Food-drug interactions often present a significant challenge during the development of oral medicines, due to their influence on drug pharmacodynamics and pharmacokinetics (PK). In particular, food may have a substantial impact on drug absorption and metabolism, which will be reflected in the measured PK parameters.

6. www.ncbi.nlm.nih.gov › pmc › articlesFood-drug interactions: Knowledge among pharmacists in Jordan

   www.ncbi.nlm.nih.gov › pmc › articles

   Jun 17, 2020 · The highest knowledge scores were for alcohol-drug interactions section (66.6%) followed by both common food-drug interactions and the timing of drug intake to food consumption sections with a score of (58.3%) for each, reflecting a suboptimal knowledge of FDIs among the pharmacists.

7. People also ask

   What are Food-Drug interactions?

   • However, the interaction between them is one of the main challenges, especially for oral medications [ 2 ]. Food-drug interactions (FDIs) are defined as alterations in drugs’ pharmacokinetics or pharmacodynamics as a result of food, or changes to nutrients caused by drugs [ 3 ].

   Food-drug interactions: Knowledge among pharmacists in Jordan

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7299397/

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   What are Food-Drug interactions (FDIs)?

   • Food–drug interactions (FDIs) are the consequence of a physical, chemical or physiologic relationship between a drug and either a product consumed as food or a dietary supplement ( 7 ). These interactions are frequent in orally administered drugs and can affect both their pharmacodynamics and their pharmacokinetics ( 8 ).

   FooDrugs: a comprehensive food–drug interactions database with text

   academic.oup.com/database/article/doi/10.1093/database/baad075/7407359

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   How does food affect drug pharmacokinetics?

   • Food-drug interactions often present a significant challenge during the development of oral medicines, due to their influence on drug pharmacodynamics and pharmacokinetics (PK). In particular, food may have a substantial impact on drug absorption and metabolism, which will be reflected in the measured PK parameters.

   Assessment of food effects during clinical development

   www.sciencedirect.com/science/article/pii/S0378517323001783

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   Are Food-Drug interactions a problem in drug discovery and development?

   • Food-drug interactions also represent a concern in drug discovery and development. While approaches to assess food effects on absorption are reasonably well established, direct food-drug interactions can be more challenging to detect.

   Drug-Drug and Food-Drug Interactions | SpringerLink

   link.springer.com/referenceworkentry/10.1007/978-3-030-51519-5_87-1

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8. link.springer.com › referenceworkentry › 10Drug-Drug and Food-Drug Interactions | SpringerLink

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   Jun 23, 2021 · Philip Butler & Robert J. Riley. 43 Accesses. Download reference work entry PDF. Definition. Pharmacokinetic drug-drug interactions (DDIs) are a significant concern in terms of patient safety and drug efficacy. Clinically relevant changes in exposure can alter the safety and efficacy profile of a drug and/or metabolite.