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The most common cancer of the urinary tract in dogs is transitional cell carcinoma (TCC), which is a cancer of the epithelial cells that line the urinary tract. This cancer most commonly occurs in older female dogs (although both males and females can be affected). Certain breeds, such as Scottish Terriers, West Highland White Terriers, beagles ...
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- Symptoms.
- Diagnosis.
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- Drug Therapy.
- Other Chemotherapy Drugs.
- Prognosis.
A diagnosis of TCC is suspected when the following symptoms are exhibited: 1. Straining to urinate or urinating small amounts frequently 2. Blood in the urine 3. Inability to urinate (obstructed bladder) These symptoms are not specific for a bladder tumor. Animals with bladder infections or bladder stones may behave the same way. A bladder tumor or...
It is rare that a bladder tumor can be felt by palpating the belly, and most bladder tumors are not seen on abdominal radiographs (x-rays). Some tests your veterinarian may recommend if a bladder tumor is suspected include urinalysis (microscopic examination of a urine sample), ultrasound of the abdomen, biopsy to confirm the diagnosis if a mass is...
Surgery may be a treatment option for cats with TCC, because the tumor tends to involve a part of the bladder that is not essential for bladder control. Surgery is often not a good treatment option for TCC in dogs because the tumor is often located in the neck of the urinary bladder. Surgery in this site may render the dog incontinent (unable to co...
Drug therapy is the most common treatment for TCC. Up to 40% of dogs with TCC may have a response to medical therapy, although that response is almost always partial. Although not all tumors shrink in response to therapy, another positive response is a decrease in the growth rate of the tumor. Medications that may have some effect against TCC in do...
Mitoxantrone, carboplatin and doxorubicin are more traditional chemotherapy drugs. The two equally important goals of chemotherapy are to control the tumor for as long as possible and maintain a good to excellent quality of life throughout the duration of treatment. Occasionally, radiation therapy may be recommended to help relieve some of the clin...
Ultimately, TCC is a fatal disease. The tumor will most frequently grow to obstruct either the urethra or the ureters, which can result in kidney failure due to obstruction. There is also the potential for metastasis (tumor spread to a distant site). With treatment, average survival times following diagnosis are between six and nine months. However...
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population of older dogs and cats. In fact, a large-scale (n . 74,000 dogs), two-decade demographic study of the Veterinary Medical Database found that neoplastic disease was the most common terminal pathological process in 73 of 82 canine breeds and the most common cause of death in dogs .1 yr of age, with an
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Jul 1, 2008 · It is recommended that renal function be monitored on a regular basis. 3. Chemotherapy: This option often is employed for the treatment of bladder tumors, either alone or in conjunction with piroxicam. The most commonly used drugs for canine TCC have been cisplatin, mitoxantrone, doxorubicin and carboplatin.
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