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Nov 21, 2020 · The pathophysiology of functional gastrointestinal disorders is complex, but involves bidirectional dysregulation of gut-brain interaction (via the gut-brain axis), as well as microbial dysbiosis within the gut, altered mucosal immune function, visceral hypersensitivity, and abnormal gastrointestinal motility.
- Christopher J Black, Douglas A Drossman, Nicholas J Talley, Johannah Ruddy, Alexander C Ford, Alexan...
- 2020
- AbstrAct
- generAl dIetAry And lIfestyle AdvIce
- specIAlIsed dIetAry AdvIce
- fIrst-lIne drug treAtments
- second-lIne drug treAtments tArgetIng AbnormAlItIes of stool form
- conclusIons
- Patient consent for publication Not required.
Irritable bowel syndrome (IBS) is a common disorder of gut- brain interaction which can have a considerable impact on quality of life. Following diagnosis, timely and evidence- based management is vital to the care of patients with IBS, aiming to improve outcomes, and enhance patient satisfaction. Good communication is paramount, and clinicians sho...
A discussion of simple dietary and lifestyle advice should be part of the care of all patients with IBS. The concept of self- help is important in empowering patients to take control of managing their condition.
If first- line dietary advice is ineffective, patients should be referred for assessment by a specialist dietitian. It is important to recognise that, although exclusion diets are commonplace in IBS management, the mechanisms by which they might work remain unclear. Dietetic assessment is key to ensuring that any diet is followed correctly, and tha...
If dietary and lifestyle advice are inadequate for improving symptoms, then a number of first- line drug treatments, targeting individual symptoms, should be considered.
As already discussed, antidiarrhoeals and laxatives can be used in the treatment of abnormal stool form; however, where these prove ineffective, second- line drugs targeting abnormalities in bowel habit are avail-able.
Once a diagnosis of IBS is made, it is important to start timely treatment. Good communication is central to managing the condition, and there should be a focus on exploring patient beliefs about the condition, and any concerns they may have. Clinicians should provide a clear explanation about the disorder, and the rationale for any investigations,...
Provenance and peer review Commissioned; externally peer reviewed.
- 898KB
- Christopher J Black, Alexander Charles Ford
- 13
- 2021
The primary aim of this guideline, commissioned by the BSG, is to review and summarise the current evidence to inform and guide clinical practice, by providing a practical framework for evidence-based diagnosis and treatment of patients.
Christopher J. Black's 115 research works with 3,161 citations and 8,780 reads, including: Novel symptom clusters predict disease impact and healthcare utilisation in inflammatory bowel...
Jul 16, 2018 · Chronic idiopathic constipation (CIC) is one of the most common gastrointestinal disorders, with a global prevalence of 14%. It is commoner in women and its prevalence increases with age. There are three subtypes of CIC: dyssynergic defaecation, slow transit constipation and normal transit constipation, which is the most common subtype.
- Christopher J Black, Alexander C Ford
- 2018
Jun 2, 2023 · Christopher J. Black, Scott B. Teasdale, Antonina Mikocka-Walus & Laurie Keefer. Nature Reviews Gastroenterology & Hepatology 20 , 582–596 ( 2023) Cite this article. 17k Accesses. 18...
Comparison of drugs for active eosinophilic oesophagitis: systematic review and network meta-analysis. Gut. 2023-11 | Journal article. DOI: 10.1136/gutjnl-2023-329873. Contributors : Pierfrancesco Visaggi; Brigida Barberio; Giulio Del Corso; Nicola de Bortoli; Christopher J Black; Alexander C Ford; Edoardo Savarino.
