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Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. JE Nestler, DJ Jakubowicz, WS Evans, R Pasquali. New England Journal of Medicine 338 (26),...
Salomon Jakubowicz's 7 research works with 951 citations and 1,270 reads, including: Effects of Metformin and Rosiglitazone, Alone and in Combination, in Nonobese Women With Polycystic Ovary...
- Subjects and Methods
- Results
- Discussion
- Abbreviations
Study subjects
We studied 141 women during the first trimester of pregnancy, defined as up to 12 wk gestation. Seventy-seven women had PCOS, and 64 were randomly selected, healthy, ovulatory women. PCOS was diagnosed before pregnancy, and defined by oligomenorrhea (eight or fewer menstrual periods annually before pregnancy) and hyperandrogenism (elevated serum free testosterone concentration or hirsutism) (31). All women with PCOS had polycystic ovaries by ultrasonography, although this was not an inclusion...
Protocol
Each woman was studied once during the first trimester of pregnancy, and they were divided into the following three groups based on fetal gestational age: 1) from the start of wk 3 through the end of wk 5 (wk 3–5), 2) from the start of wk 6 through the end of wk 8 (wk 6–8), and 3) from the start of wk 9 through the end of wk 11 (wk 9–11). Gestational age was defined as the number of weeks since the last menstrual period. Pregnancy was confirmed by a urine pregnancy test or serum human chorion...
Assays
Blood samples were centrifuged immediately after collection, and serum was stored at −20 C until assayed. Serum glycodelin and IGFBP-1 were assayed in Helsinki by sandwich-type immunofluorometry, as previously described (32, 33). Serum insulin was measured by a highly specific RIA (Diagnostic Products, Los Angeles, CA) that had cross-reactivity with proinsulin of approximately 40% at midcurve. Serum hormones and SHBG, measured as protein, were assayed in Richmond, Virginia, using commercial k...
Clinical characteristics
Of the 141 pregnant women who entered the study, 7 were withdrawn because they received hormonal therapy with hCG. This left 134 women, 72 with PCOS and 62 normal women. Clinical characteristics of the study populations are given in Table 1. By chance, there were no significant differences in age and body mass index between the women with PCOS and normal women. Women with PCOS had significantly younger ages at menarche compared with normal women, and tended to have higher rates of past EPL th...
EPL
Of the 134 women studied, EPL occurred subsequent to the study in 12 women. Ten were women with PCOS, and two were normal women. Fifty percent of the miscarriages occurred during wk 3–5, 30% during wk 6–8, and 20% during wk 9–11. Women with PCOS had significantly more miscarriages compared with normal women (14 vs. 3%, respectively; P= 0.02). There were no significant clinical and metabolic differences between the women with PCOS and normal women who miscarried. In the PCOS group, there were...
The aim of this study was to test the hypothesis that serum glycodelin and IGFBP-1 concentrations would be decreased in pregnant women with PCOS during the first trimester. Indeed, during the first 2 months (wk 3–8) of pregnancy, both serum glycodelin and IGFBP-1 levels were strikingly lower in women with PCOS compared with normal women. During the...
EPL,Early pregnancy loss;hCG,human chorionic gonadotropin;IGFBP-1,IGF binding protein-1;ISI,insulin sensitivity index;- Daniela J. Jakubowicz, Paulina A. Essah, Markku Seppälä, Salomon Jakubowicz, Jean-Patrice Baillargeo...
- 2004
Dec 3, 2019 · A new study finds that a starch-rich breakfast consumed early in the morning coupled with a small dinner could replace insulin injections and other diabetes medications for many diabetics.
University, Richmond, Virginia Objective: To determine whether insulin-sensitizing drugs would improve ovulation and T levels in women with polycystic ovary syndrome (PCOS), without clinical or biochemical criteria indicating insulin resistance
Feb 1, 2002 · Clinical care was provided to the patients by a single endocrinologist (D. J. Jakubowicz), who used metformin to facilitate fertility or as chronic therapy in the polycystic ovary syndrome, and whose practice it is to continue metformin administration throughout pregnancy.
daniela j. jakubowicz, paulina a. essah, markku seppa¨la¨, salomon jakubowicz, jean-patrice baillargeon, riitta koistinen, and john e. nestler
