Search results
Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity. JP Baillargeon, DJ Jakubowicz, MJ...
Salomon Jakubowicz's 7 research works with 951 citations and 1,270 reads, including: Effects of Metformin and Rosiglitazone, Alone and in Combination, in Nonobese Women With Polycystic Ovary...
Salomon Jakubowicz; Phones (954) 391-9184; Addresses: 1475 Commodore Way, Hollywood, FL 33019; 3801 Ne 207Th St Apt 38, Miami, FL 33180; Occupations: Mã Dico in Ni Una Dieta Más; Managing in No More Diet, LLC; Educations: Universidad Simón Bolívar; Age Range: 47 to 65
Salomon Jakubowicz is an academic researcher from Central University of Venezuela. The author has contributed to research in topics: Polycystic ovary & Metformin. The author has an hindex of 5, co-authored 5 publications receiving 1019 citations.
- Materials and Methods
- Results
- Discussion
- Acknowledgments
- Abbreviations
Study subjects
We examined the records of all 96 nondiabetic women with the polycystic ovary syndrome who became pregnant while being seen in the Endocrinology Clinic of the Hospital de Clinicas Caracas between January 1996 and June 2000, and who either did not receive metformin at the time of conception or during pregnancy (control group; n = 31) or became pregnant while taking metformin and continued taking metformin at a dose of 1000–2000 mg daily throughout pregnancy (metformin group; n = 65). Polycysti...
Assessments of subjects
Clinical care was provided to the patients by a single endocrinologist (D. J. Jakubowicz), who used metformin to facilitate fertility or as chronic therapy in the polycystic ovary syndrome, and whose practice it is to continue metformin administration throughout pregnancy. All women were offered metformin to facilitate pregnancy, and women in the control group either elected not to use metformin or discontinued using metformin before conception because of side effects of the drug (diarrhea or...
Determination of pregnancy.
Pregnancy was confirmed by a urine pregnancy test or plasma β-human CG (β-hCG) more than 50 IU/liter and by detection of a gestational sac in the uterine cavity, by ultrasonography. Principal ultrasonographic determinants of pregnancy outcome were also assessed, including maximum gestation-sac diameter, crown-rump length, and embryonic heart rate.
History of previous pregnancy outcomes
With regard to previous pregnancy outcomes, 48 of the 65 women in the metformin group had a history of at least 1 prior pregnancy, whereas 17 women were nulliparous. None of the women had received metformin during these previous pregnancies. Among the 48 women in the metformin group with a history of prior pregnancy, there were a total of 75 pregnancies, which resulted in 22 live births and 53 miscarriages, yielding a miscarriage rate of 70.7%. In the control group, 21 of the 31 women had a h...
Baseline characteristics
Table 1describes the baseline anthropometric and hormonal variables for the metformin and control groups, which did not differ with respect to age, body mass index, fasting serum glucose and insulin concentrations, fasting serum glucose-to-insulin ratio, serum free T concentration, and treatment with either clomiphene citrate or hCG for ovulation induction.
Stratification of groups
Stratification of the women is depicted in Fig. 1. The women in each of the two groups were stratified into 2 subgroups: 1) women with previous history of early pregnancy loss (EPL+); and (2) women with no history of previous miscarriage (EPL−). The women who were EPL− were either nulliparous women or women with previous pregnancies completed to term. Of the 65 women in the metformin group, 34 (52.3%) were in the EPL+ group and 31 (47.7%) were in the EPL− group (17 women were nulliparous, and...
When women with polycystic ovary syndrome finally achieve pregnancy (often after a long, arduous, and expensive course of fertility treatments), they are faced with the distressing prospect of a substantially increased risk for miscarriage during the first trimester (5–7). The findings of this study support the hypothesis that decreasing hyperinsul...
This work was supported, in part, by NICHD/NIH through cooperative agreement U54HD96008 as part of the Specialized Cooperative (to J.E.N.), K24HD40237 (to J.E.N.) and NCRR M01RR00065-37S1 (to M.J.I.).
EPL+,Previous history of early pregnancy loss;EPL−,no previous history of early pregnancy loss;hCG,human CG.- Daniela J. Jakubowicz, Maria J. Iuorno, Salomon Jakubowicz, Katherine A. Roberts, John E. Nestler
- 2002
Daniela JAKUBOWICZ | Cited by 8,038 | of Tel Aviv University, Tel Aviv (TAU) | Read 72 publications | Contact Daniela JAKUBOWICZ.
Maria J. Iuorno, M.D. Salomon Jakubowicz, M.D. John E. Nestler, M.D. DOI: https://doi.org/10.1016/j.fertnstert.2004.02.127. Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity. Objective.
