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      • A review of the literature finds that AEDs, particularly those that block sodium channels and/or have GABA-related mechanisms of action, are effective in reducing the frequency and intensity of impulsive aggressive outbursts both when used as the primary agent of treatment and as an adjunct to ongoing pharmacotherapy.
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  2. Four antiepileptic drugs (valproate/divalproex, carbamazepine, oxcarbazepine and phenytoin) helped to reduce aggression in at least one study. However, for three of these drugs (valproate, carbamazepine and phenytoin) we found at least one other study where there was no significant improvement.

  3. Feb 17, 2010 · Antiepileptic drugs may reduce aggression by acting on the central nervous system to reduce neuronal hyper-excitability associated with aggression. Objectives: To evaluate the efficacy of antiepileptic drugs in reducing aggression and associated impulsivity.

    • Nick Huband, Michael Ferriter, Rajan Nathan, Hannah Jones
    • 2010
  4. Strong evidence for efficacy in impulsive aggression exists from randomized controlled trials for most of the common AEDs (phenytoin, carbamazepine, oxcarbazepine, lamotrigine, valproate/divalproex sodium, topiramate). Additional controlled studies are needed for tiagabine and gabapentin.

    • Matthew S. Stanford, Nathaniel E. Anderson, Sarah L. Lake, Robyn M. Baldridge
    • 2009
  5. We review here evidence that suggest that antiepileptic drugs (AEDs) (a.k.a. anti- convulsants) may be effective for the treatment of impulsivity and aggression across a range of psychiatric disorders.

  6. Do antiepileptic drugs reduce aggression and associated impulsivity? Outcomes: Primary outcome: observer or self-reported aggression (Overt Aggression Scale (OAS), modified forms of the OAS (OAS-M, MOAS), self-reported incidents, Children's Psychiatric Rating Scale (CPRS) aggression subscale).

  7. Anti-Epileptic Drugs (AEDs) have become an appealing alternative in the treatment of aggression, mood lability and impulsivity in adult and pediatric populations, although few controlled trials have explored their efficacy in treating pediatric populations.

  8. Antiepileptic drugs may reduce aggression by acting on the central nervous system to reduce neuronal hyper-excitability associated with aggression. Objectives: To evaluate the efficacy of antiepileptic drugs in reducing aggression and associated impulsivity.

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    related to: are antiepileptic drugs effective for impulsive aggression among
  2. Ready to make the DIACOMITment? Visit The Official HCP Site for DIACOMIT® (stiripentol). With DIACOMIT, you have options. Choose from capsules or powder for oral suspension.

  3. Learn More About Episodes Of Frequent Seizures & The Importance Of Rescue Treatments. Discover An FDA-Approved Rescue Nasal Spray For Patients With Frequent Seizure Episodes.

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