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- A review of the literature finds that AEDs, particularly those that block sodium channels and/or have GABA-related mechanisms of action, are effective in reducing the frequency and intensity of impulsive aggressive outbursts both when used as the primary agent of treatment and as an adjunct to ongoing pharmacotherapy.
pubmed.ncbi.nlm.nih.gov/19744405/
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Antiepileptic drugs may reduce aggression by acting on the central nervous system to reduce neuronal hyper‐excitability associated with aggression. Objectives To evaluate the efficacy of antiepileptic drugs in reducing aggression and associated impulsivity.
### Question: Do antiepileptic drugs reduce aggression and associated impulsivity? ### Outcomes: Primary outcome: observer or self-reported aggression (Overt Aggression Scale (OAS), modified forms of the OAS (OAS-M, MOAS), self-reported incidents, Children's Psychiatric Rating Scale (CPRS) aggression subscale).
In recent years, antiepileptic drugs (AEDs) have become increasingly popular for the management of impulsive (reactive) aggressive behavior. The research literature has implicated several neurobiologic deficits associated with impulsive aggression, including reduced central serotonergic functioning, executive dysfunction, and prefrontal deficits.
- Matthew S. Stanford, Nathaniel E. Anderson, Sarah L. Lake, Robyn M. Baldridge
- 2009
Antiepileptic drugs may reduce aggression by acting on the central nervous system to reduce neuronal hyper-excitability associated with aggression. Objectives: To evaluate the efficacy of antiepileptic drugs in reducing aggression and associated impulsivity.
Antiepileptic drugs (AEDs) have many benefits but also many side effects, including aggression, agitation, and irritability, in some patients with epilepsy. This article offers a comprehensive summary of current understanding of aggressive behaviors in patients with epilepsy, including an evidence-b …
- Martin J. Brodie, Frank Besag, Frank Besag, Alan B. Ettinger, Marco Mula, Marco Mula, Gabriella Gobb...
- 2016
This article offers a comprehensive summary of current understanding of aggressive behaviors in patients with epilepsy, including an evidence-based review of aggression during AED treatment. Aggression is seen in a minority of people with epilepsy.
Anti-Epileptic Drugs (AEDs) have become an appealing alternative in the treatment of aggression, mood lability and impulsivity in adult and pediatric populations, although few controlled trials have explored their efficacy in treating pediatric populations.
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