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1. www.nature.com › articles › nrn3820Polyunsaturated fatty acids and their metabolites in brain ...

   www.nature.com › articles › nrn3820

   Nov 12, 2014 · The brain is especially enriched with the two polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid. Although, quantitatively speaking, they are primarily esterified to brain ...

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2. pmc.ncbi.nlm.nih.gov › articles › PMC8910658Fatty Acids: An Insight into the Pathogenesis of ...

   pmc.ncbi.nlm.nih.gov › articles › PMC8910658

   Oct 29, 2024 · Schönfeld P., Reiser G. Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy?-Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain. J. Cereb. Blood Flow Metab. 2013;33:1493–1499. doi: 10.1038/jcbfm.2013.128. [PMC free article] [Google Scholar] 49.

3. www.sciencedirect.com › science › articleFats for thoughts: An update on brain fatty acid metabolism

   www.sciencedirect.com › science › article

   Mar 1, 2017 · The human brain has a high energy demand that is almost exclusively satisfied metabolizing glucose and, under particular circumstances, also fatty acids (FAs) and ketone bodies (KBs) (Fig. 1) (Belanger et al., 2011). However, the energetic role of FA oxidation in the brain is still matter of debate.

   • Author: Adele Romano, Justyna Barbara Koczwara, Cristina Anna Gallelli, Daniele Vergara, Maria Vittoria Mici...

   • Publish Year: 2017

4. pmc.ncbi.nlm.nih.gov › articles › PMC9836261Functional consequences of brain exposure to saturated fatty ...

   pmc.ncbi.nlm.nih.gov › articles › PMC9836261

   Saturated fatty acids (FAs) are the main component of high‐fat diets (HFDs), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and mitochondrial dysfunction in neuronal cells.

5. pmc.ncbi.nlm.nih.gov › articles › PMC6120115Impact of Dietary Fats on Brain Functions - PMC

   pmc.ncbi.nlm.nih.gov › articles › PMC6120115

   The mode of action of OEA illustrates a case of lipid-derived sensor of dietary fats connecting food intake and fatty acids sensing in the gut to hypothalamic fatty acids sensing. Although controversial as for the subdiaphragmatic vagal deafferentation [ 101 ], OEA-induced hypophagia is abolished in case vagal sensory afferents are lost as for pharmacological treatment or surgical resection ...

6. www.frontiersin.org › journals › neuroscienceDiet-Derived Fatty Acids, Brain Inflammation, and Mental Health

   www.frontiersin.org › journals › neuroscience

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   Neuroinflammation stands out as a hallmark feature of brain disorders that may be linked to peripheral metabolic dyshomeostasis caused by an unhealthy diet. Dietary fatty acids are of particular interest, as they may play a dual role, both as a component of high-calorie obesogenic diets and as signaling molecules involved in inflammatory responses.

7. People also ask

   How do fatty acids affect brain function?

   • Lipids account for nearly 60% of human brain tissue and the composition of fatty acids (FAs) seems to impact on brain integrity and function [ 1 ]. FAs are the elementary building blocks of triglycerides, phospholipids and cholesteryl esters. They function as energy sources and are important structural components of all cells.

   The relationship between plasma free fatty acids, cognitive function

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8507298/

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   What fatty acids are found in the brain?

   • The brain is especially enriched with the two polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid. Although, quantitatively speaking, they are primarily esterified to brain phophospholipids, they can be released from the membrane and transformed into highly biologically active molecules.

   Polyunsaturated fatty acids and their metabolites in brain function and

   www.nature.com/articles/nrn3820

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   Is fatty acid oxidation a function of the brain?

   • The human brain has a high energy demand that is almost exclusively satisfied metabolizing glucose and, under particular circumstances, also fatty acids (FAs) and ketone bodies (KBs) (Fig. 1) (Belanger et al., 2011). However, the energetic role of FA oxidation in the brain is still matter of debate.

   Fats for thoughts: An update on brain fatty acid metabolism

   www.sciencedirect.com/science/article/pii/S1357272516304058

   See all results for this question

   How do fatty acids enter the brain?

   • Fatty acids enter the brain and cells through FATPs. Within the cells, fatty acids (FAs) can be β‐oxidized by mitochondria (for FAs 2‐18 carbon atoms in length) or by peroxisomes (for 28‐carbon FAs). Palmitic acid metabolism can impact the hypothalamic energy sensing neurons, resulting in a loss of energy homeostasis.

   Functional consequences of brain exposure to saturated fatty acids

   pmc.ncbi.nlm.nih.gov/articles/PMC9836261/

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   Are essential fatty acids mediators of brain biochemistry and cognitive functions?

   • Essential fatty acids are mediators of brain biochemistry and cognitive functions. J. Neurosci. Res. 56, 565–570. doi: 10.1002/ (SICI)1097-4547 (19990615)56:6<565::AID-JNR2>3.0.CO;2-H Yirmiya, R., Rimmerman, N., and Reshef, R. (2015).

   Diet-Derived Fatty Acids, Brain Inflammation, and Mental Health

   www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2019.00265/full

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8. www.ncbi.nlm.nih.gov › pmc › articlesThe relationship between plasma free fatty acids, cognitive ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 9, 2021 · Lipids account for nearly 60% of human brain tissue and the composition of fatty acids (FAs) seems to impact on brain integrity and function . FAs are the elementary building blocks of triglycerides, phospholipids and cholesteryl esters. They function as energy sources and are important structural components of all cells.