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1. www.ncbi.nlm.nih.gov › pmc › articlesHuman adaptation over the past 40,000 years - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   While recognizing that non-genetic mechanisms of adaptation such as developmental plasticity and cultural evolution are powerful forces, this review focuses on recent developments related to the detection, classification and interpretation of natural selection in the human genome.

   • Genetic and Non-Genetic Mechanisms Underlying Cancer Evolution

     Non-genetic mechanisms (histones and DNA modifications,...

2. www.ncbi.nlm.nih.gov › pmc › articlesGenetic and Non-Genetic Mechanisms Underlying Cancer Evolution

   www.ncbi.nlm.nih.gov › pmc › articles

   Mar 18, 2021 · Non-genetic mechanisms (histones and DNA modifications, imprinting, paramutation, posttranslational gene silencing, etc.) can lead to the establishment of metastable and stable phenotypic states that can be inherited upon cell division and propagated through many cell generations.

   • Author: Yelyzaveta Shlyakhtina, Katherine L. Moran, Maximiliano M. Portal
   • DOI: 10.3390/cancers13061380

   • Publish Year: 2021
   • Publication: Cancers (Basel). 2021 Mar; 13(6): 1380.

3. Videos

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     Natural selection and adaptation | Mechanisms of evolution | High school biology | Khan Academy

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4. www.nature.com › articles › s41568/020/00302-4Non-genetic mechanisms of therapeutic resistance in cancer

   www.nature.com › articles › s41568/020/00302-4

   Oct 8, 2020 · This Perspective discusses how therapeutic resistance is not only driven by genetic evolution but often involves non-genetic adaptive mechanisms that are intimately linked.

   • Author: Jean-Christophe Marine, Sarah-Jane Dawson, Sarah-Jane Dawson, Mark A Dawson, Mark A Dawson

   • Publish Year: 2020

5. www.nature.com › articles › s41576/020/0250-zPolygenic adaptation: a unifying framework to understand ...

   www.nature.com › articles › s41576/020/0250-z

   Jun 29, 2020 · Because adaptation can be typically achieved by many different combinations of adaptive alleles (redundancy), we describe how two characteristics — heterogeneity among loci and non-parallelism...

   • Author: Neda Barghi, Joachim Hermisson, Christian Schlötterer

   • Publish Year: 2020

6. www.nature.com › articles › s41586/024/07302-6Decoding the interplay between genetic and non-genetic ...

   www.nature.com › articles › s41586/024/07302-6

   May 15, 2024 · Here we review a growing body of literature highlighting the importance of both genetic and non-genetic reprogramming events during the metastatic cascade, and discuss how genetic and...

   • Author: Panagiotis Karras

7. pubmed.ncbi.nlm.nih.gov › 33033407Non-genetic mechanisms of therapeutic resistance in cancer

   pubmed.ncbi.nlm.nih.gov › 33033407

   The prevalence and diverse array of non-genetic resistance mechanisms pose a new challenge to the field that requires innovative strategies to monitor and counteract these adaptive processes. In this Perspective we discuss the key principles of non-genetic therapy resistance in cancer.

8. People also ask

   Are non-genetic mechanisms of adaptation a powerful force?

   • While recognizing that non-genetic mechanisms of adaptation such as developmental plasticity and cultural evolution are powerful forces, this review focuses on recent developments related to the detection, classification and interpretation of natural selection in the human genome.

   Human adaptation over the past 40,000 years - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7484260/

   See all results for this question

   Does non-genetic adaptation contribute to cancer resistance?

   • Preliminary findings suggest that non-genetic adaptation is likely to be a pervasive and significant component of cancer resistance, therefore it is important that we carefully assess its relative contribution across a wide range of cancer and treatment contexts.

   Principles and mechanisms of non-genetic resistance in cancer - PMC - …

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7028722/

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   Are there genetic and non-genetic mechanisms of resistance in cancer?

   • The true prevalence of genetic and non-genetic mechanisms of resistance in cancer is largely unknown, and the molecular mechanisms underlying non-genetic resistance remain elusive.

   Non-genetic mechanisms of therapeutic resistance in cancer

   www.nature.com/articles/s41568-020-00302-4

   See all results for this question

   What is the difference between population genetics and phenotypic adaptation?

   • Building on disjointed data sets, both schools developed diverging narratives of phenotypic adaptation: whereas quantitative genetics envisions adaptation via subtle allele frequency shifts at many loci, population genetics predicts independent selective sweeps, leading to phenotypic adaptation via single-locus mutations.

   Polygenic adaptation: a unifying framework to understand ... | Nature

   www.nature.com/articles/s41576-020-0250-z

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   Are genetic and non-genetic mechanisms underlying tumour evolution?

   • Herein, we discuss an up-to-date view of the fundamental genetic and non-genetic mechanisms underlying tumour evolution with the aim of concurring into an integrated view of the evolutionary forces at play throughout the emergence and progression of the disease and into the acquisition of resistance to diverse therapeutic paradigms.

   Genetic and Non-Genetic Mechanisms Underlying Cancer Evolution

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8002988/

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   Do non-genetic mechanisms play a role in cancer evolution?

   • Although for decades cancer has been viewed as a process governed by genetic mechanisms, it is becoming more and more clear that non-genetic mechanisms may play an equally important role in cancer evolution.

   Genetic and Non-Genetic Mechanisms Underlying Cancer Evolution

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8002988/

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9. www.ncbi.nlm.nih.gov › pmc › articlesPrinciples and mechanisms of non-genetic resistance in cancer

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 2, 2020 · Drug resistance can arise through purely non-genetic changes, purely genetic changes, initial non-genetic changes then genetic changes, or non-genetic changes within a particular genotype. Cancer cells will use the adaptive pathway that results in the most rapid or highest degree of drug resistance.