Yahoo Canada Web Search

Search results

1. www.nature.com › articles › s41580/018/0009-yMicrotubule dynamics: an interplay of biochemistry and ...

   www.nature.com › articles › s41580/018/0009-y

   Apr 19, 2018 · It has become apparent that microtubule-associated proteins (MAPs) selectively target specific tubulin conformations to regulate microtubule dynamics, and mechanical forces can also influence ...

   • Metrics

     Metrics - Microtubule dynamics: an interplay of biochemistry...

   • Full Size Image

     Full Size Image - Microtubule dynamics: an interplay of...

   • View Author Publications

     View Author Publications - Microtubule dynamics: an...

2. www.sciencedirect.com › science › articlePhotoswitchable Inhibitors of Microtubule Dynamics Optically ...

   www.sciencedirect.com › science › article

   Jul 16, 2015 · Here, we introduce the photostatins, inhibitors that can be switched on and off in vivo by visible light, to optically control microtubule dynamics. Photostatins modulate microtubule dynamics with a subsecond response time and control mitosis in living organisms with single-cell spatial precision.

   • Author: Malgorzata Borowiak, Malgorzata Borowiak, Wallis Nahaboo, Martin Reynders, Katharina Nekolla, Pierre...

   • Publish Year: 2015

3. Videos

   • 

     3:09

     youtube.com

     Dynamic Instablity Of Microtubules | Microtubule Dynamics |

     Aug 5, 2020

     11.4K Views

   • 

     0:18

     youtube.com

     Microtubule dynamics in live cells

     Jul 16, 2009

     23.5K Views

   • 

     4:10

     youtube.com

     Dynamic Instability Of Microtubules

     Apr 21, 2014

     191.1K Views

   View all

4. www.nature.com › articles › s41467/020/18389-6Photoswitchable paclitaxel-based microtubule stabilisers ...

   www.nature.com › articles › s41467/020/18389-6

   Sep 15, 2020 · Photoisomerising these reagents in living cells allows optical control over microtubule network integrity and dynamics, cell division and survival, with biological response on the timescale of ...

   • Author: Adrian Müller-Deku, Joyce C. M. Meiring, Kristina Loy, Yvonne Kraus, Constanze Heise, Rebekkah Bingh...

   • Publish Year: 2020

5. www.cell.com › cell › fulltextOptical Control of Microtubule Dynamics in Time and Space

   www.cell.com › cell › fulltext

   Jul 16, 2015 · Small molecule inhibitors of microtubule dynamics are widely used as cell biology research tools and clinically as cancer chemotherapeutics. By slight modification to the chemical structure of a known microtubule inhibitor, combretastatin A-4, Borowiak et al. develop a photoswitchable derivative that can be turned “on” and “off” with low-intensity light to spatially and temporally ...

   • Author: Brian T. Castle, David J. Odde

   • Publish Year: 2015

6. www.nature.com › articles › s41580/021/00399-xRegulation of microtubule dynamics, mechanics and function ...

   www.nature.com › articles › s41580/021/00399-x

   Aug 18, 2021 · In addition, this group showed that forces exerted on microtubules can modify microtubule dynamics, either speeding or slowing microtubule growth and shortening, depending on the direction of the ...

   • Author: Nikita B Gudimchuk, Nikita B Gudimchuk, J Richard McIntosh

   • Publish Year: 2021

7. www.sciencedirect.com › science › articleLights, cytoskeleton, action: Optogenetic control of cell ...

   www.sciencedirect.com › science › article

   Oct 1, 2020 · For example, kinesin motor activity in the absence of cargo-binding can still affect microtubule network organization. To improve dynamic range and specificity of light-activated transport systems, the Kapitein group most recently introduced a two-step system in which both cargo binding and motor processivity are blue light-activated [ 29 ].

8. People also ask

   Do small molecules interfere with microtubule dynamics?

   • Small molecules that interfere with microtubule dynamics, such as Taxol and the alkaloids, are widely used in cell biology research and as clinical anticancer drugs. However, their activity cannot be restricted to specific target cells, which also causes severe side effects in chemotherapy.

   Photoswitchable Inhibitors of Microtubule Dynamics Optically

   www.sciencedirect.com/science/article/pii/S0092867415007746

   See all results for this question

   How does dynamic instability affect microtubule-chromosome encounter?

   • This use of dynamic instability dramatically increases the rate at which chromosomes attach to microtubules, compared with a scenario based on microtubules whose lengths remain constant 8, 9. It is now clear, however, that cells use additional cues such as gradients of Ran-GTP to increase the efficiency of microtubule–chromosome encounter 10.

   Regulation of microtubule dynamics, mechanics and function ... - N…

   www.nature.com/articles/s41580-021-00399-x

   See all results for this question

   How do cells control microtubule dynamics?

   • By modulating configurations of those intermediates in different ways, cells exert control on microtubule dynamics to fine-tune their behaviour for a broad spectrum of functions. Here, we summarize evidence about tip structures in cells and their cellular control by microtubule-associated proteins, small-molecule drugs and mechanical forces.

   Regulation of microtubule dynamics, mechanics and function ... - N…

   www.nature.com/articles/s41580-021-00399-x

   See all results for this question

   How do maps affect microtubule dynamics?

   • It has become apparent that microtubule-associated proteins (MAPs) selectively target specific tubulin conformations to regulate microtubule dynamics, and mechanical forces can also influence microtubule dynamics by altering the balance of tubulin conformations.

   Microtubule dynamics: an interplay of biochemistry and ... - Nature

   www.nature.com/articles/s41580-018-0009-y

   See all results for this question

   What factors influence microtubule dynamics in cells?

   • Additional important factors influencing microtubule dynamics in cells are the forces that can act at their tips. Growing microtubules experience compressive loads when they encounter an intracellular structure, such as the nucleus or the cell cortex.

   Regulation of microtubule dynamics, mechanics and function ... - N…

   www.nature.com/articles/s41580-021-00399-x

   See all results for this question

   How do Photostatins affect microtubule dynamics?

   • Photostatins modulate microtubule dynamics with a subsecond response time and control mitosis in living organisms with single-cell spatial precision. In longer-term applications in cell culture, photostatins are up to 250 times more cytotoxic when switched on with blue light than when kept in the dark.

   Photoswitchable Inhibitors of Microtubule Dynamics Optically

   www.sciencedirect.com/science/article/pii/S0092867415007746

   See all results for this question

9. www.cell.com › cell-chemical-biology › fulltextA Robust, GFP-Orthogonal Photoswitchable Inhibitor Scaffold ...

   www.cell.com › cell-chemical-biology › fulltext

   Feb 18, 2021 · Photocontrollable reagents have unique potential as high spatiotemporal precision modulators of biological systems. Here, Gao et al. demonstrate a GFP-orthogonal and metabolically stable photoswitch that allows optical control over microtubule dynamics and architecture with subcellular resolution. The photoswitch scaffold also offers new possibilities for photopharmaceutical design against ...