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Apr 19, 2018 · We also describe new data that emphasize the importance of the tubulin conformational cycle for understanding how microtubule dynamics generate forces and how forces can affect microtubule dynamics.
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May 24, 2021 · One reason that numerous models for microtubule growth exist in the field is that there are a range of reasonable assumptions that can be made that result in quite different mechanisms of growth. Therefore, without the ability to measure the kinetics of single tubulin dimers directly, it is difficult to limit the range of bond strengths and on-rates used to model microtubule growth.
- Joseph M. Cleary, William O. Hancock
- 2021
Aug 18, 2021 · In addition, this group showed that forces exerted on microtubules can modify microtubule dynamics, either speeding or slowing microtubule growth and shortening, depending on the direction of the ...
- Nikita B Gudimchuk, Nikita B Gudimchuk, J Richard McIntosh
- 2021
Sep 15, 2020 · Photoisomerising these reagents in living cells allows optical control over microtubule network integrity and dynamics, cell division and survival, with biological response on the timescale of ...
- Adrian Müller-Deku, Joyce C. M. Meiring, Kristina Loy, Yvonne Kraus, Constanze Heise, Rebekkah Bingh...
- 2020
Microtubule-inhibiting small molecules are crucial for cell biology research and in cancer therapy. Photostatins are microtubule inhibitors that can be switched on and off in vivo by visible light, modulating microtubule dynamics with subsecond response time, and controlling mitosis with single-cell spatial precision. Photostatins are also 250 times more cytotoxic under blue light than when ...
- Malgorzata Borowiak, Malgorzata Borowiak, Wallis Nahaboo, Martin Reynders, Katharina Nekolla, Pierre...
- 2015
Oct 1, 2020 · For example, kinesin motor activity in the absence of cargo-binding can still affect microtubule network organization. To improve dynamic range and specificity of light-activated transport systems, the Kapitein group most recently introduced a two-step system in which both cargo binding and motor processivity are blue light-activated [ 29 ].
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Feb 1, 2018 · This has raised the need for a better understanding of how various drugs stabilize microtubule dynamics and how we can rationally identify combination therapies to limit the resistance problem. In one such study [ 46 • ], eribulin, a vinca-binding drug used to treat patients with metastatic breast cancer resistant to taxanes [ 47 ], was explored for its effects on microtubule stabilization.
