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Nov 22, 2019 · A key component of the body’s oxygen-sensing system is a set of molecular hypoxia-inducible factors, or HIFs, which can respond to a need for more oxygen by turning on genes and proteins that recruit new networks of blood vessels. Cancer cells in a growing tumor can adapt to oxygen deprivation by hijacking these HIFs.
- William G. Kaelin Jr., MD
The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing...
- Research
Bispecific antibody therapies are a type of immunotherapy...
- Dana-Farber Staff
For years, patients with advanced forms of gastric and...
- William G. Kaelin Jr., MD
Jun 26, 2018 · The answers are still not definitive, but some have used the unknowns to fuel unsupported claims that certain types of oxygen therapies, including hyperbaric oxygen (HBO) therapy, can cure cancer. “A lot of people have used myths in a bad way to promise hope to cancer patients who are seeking hope and have not been given any hope in order to take their money in exchange for a therapy that ...
- Study Design and Population
- Study Variables
- Statistical Analysis
This was a cohort study conducted at a primary care practice in suburban Tokyo. Adult patients aged 20 years or older with locally advanced or metastatic cancer followed by a home medical care service provided by the practice were screened. Patients with first low oxygen saturation (peripheral arterial oxygen saturation measured by pulse oximetry <...
All data on study variables were obtained by retrospective chart review. The exposure was the use of oxygen at home. The decision regarding whether to start supplemental oxygen was made following discussion between the patient, the family and the physician. The patient and family’s wishes were respected. Whether to recommend supplemental oxygen was...
Medians with corresponding interquartile range (IQR) were calculated for overall survival and survival at home using the Kaplan–Meier survival function. The statistical significance of estimates from Kaplan–Meier survival curves for overall survival and survival at home were tested using the log-rank test. The statistical significance of the differ...
- Hiroshi Igarashi, Motoharu Fukushi, Naoki Nago
- 2020
Jan 1, 2020 · In addition, the HIFs change how cancer cells metabolize glucose (sugar) so that it can still be used to make energy even in the absence of oxygen. Consequently, as a result of the discovery of this oxygen-sensing system by Kaelin and his co-awardees, anticancer drugs are being developed that thwarting tumor growth by directly blocking HIF activity or some of the consequences of HIF activation.
Jul 10, 2023 · A long-standing staple of cancer management, radiation therapy, also called radiotherapy, is used to treat more than half of all patients with cancer. With this method, clinicians use high doses of radiation to kill cancer cells. But many tumors are resistant to radiotherapy, and hypoxia is one of the major reasons why, Eisenbrey said.
Oxygen delivery to tissues is dependent on several factors, mainly blood flow, oxygen content, and oxygen tension. 94 Recognizing the deficiencies of oxygen delivery in solid tumors, the landmark publication of Thomlinson and Gray 6 ushered in the era of hyperbaric oxygen use in the treatment of cancer. Hyperbaric chambers were designed to alter both oxygen content and partial pressure by ...
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However, in patients with chronic breathlessness despite other evidence-based treatments, a trial of supplemental oxygen could be justified,101 based on indirect data that supplemental oxygen can improve exercise capacity and breathlessness observed during exercise testing in the laboratory for patients with COPD and interstitial lung disease.99 102 Individualised information and shared ...
