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Nov 22, 2019 · A key component of the body’s oxygen-sensing system is a set of molecular hypoxia-inducible factors, or HIFs, which can respond to a need for more oxygen by turning on genes and proteins that recruit new networks of blood vessels. Cancer cells in a growing tumor can adapt to oxygen deprivation by hijacking these HIFs.
Jul 10, 2023 · For most of our tissues and cells, a lack of oxygen, or hypoxia, is bad news. Cancer cells, on the other hand, can thrive in these hypoxic conditions, which render tumors less susceptible to anti-cancer treatments, including radiation. Now, new research may offer a way to break through cancer’s hypoxia-induced defenses.
Nov 7, 2019 · The experiments mapping the “fate” of the cells in two- and three-dimensional lab-created tissue systems and in live animals specifically showed that cells from a primary cancer exposed to low oxygen levels, or hypoxia, have a four times greater probability of becoming viable circulating tumor cells—and likely spreading to distant tissues—than those under normal oxygen conditions.
Jan 1, 2020 · A key component of the body’s oxygen-sensing system is a set of molecular hypoxia-inducible factors, or HIFs, which can respond to a need for more oxygen by turning on genes and proteins that recruit new networks of blood vessels. Cancer cells in a growing tumor can adapt to oxygen deprivation by hijacking these HIFs.
Abstract. During the last century, it has been established that regions within solid tumors experience mild to severe oxygen deprivation, due to aberrant vascular function. These hypoxic regions are associated with altered cellular metabolism, as well as increased resistance to radiation and chemotherapy. As discussed in this Timeline, over the ...
This altered metabolism is often compensating for genetic and epigenetic alterations forcing tumor cells to adopt alternative strategies to generate energy as well as amino acids, fatty acids (FAs), and other metabolites necessary for cancer cell survival and proliferation and can lead to the production and accumulation of reactive oxygen species, contributing to the generation of additional ...
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Mar 14, 2024 · News. Researchers at the Francis Crick Institute have shed light on how cancer cells survive in the first few hours after being cut off from a supply of oxygen. Published today in The EMBO Journal, this finding could one day help to prevent cancer from becoming resistant to therapy. A major use of oxygen by cells is for energy production.
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