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Nov 22, 2019 · Another unproven idea about oxygen and cancer is that, since many tumors thrive in oxygen-deprived (hypoxic) conditions, giving cancer cells extra oxygen might shut them down or even kill them. That’s the notion behind hyperbaric oxygen therapy — oxygen administered to a patient in a chamber under high pressure to increase its concentration in the blood, as it sometimes done to improve ...
- William G. Kaelin Jr., MD
The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing...
- Research
BCL2 inhibitors are drugs that prompt cancer cells to die by...
- Dana-Farber Staff
Uterine cancer — also known as endometrial cancer — has...
- William G. Kaelin Jr., MD
Nov 7, 2019 · The experiments mapping the “fate” of the cells in two- and three-dimensional lab-created tissue systems and in live animals specifically showed that cells from a primary cancer exposed to low oxygen levels, or hypoxia, have a four times greater probability of becoming viable circulating tumor cells—and likely spreading to distant tissues—than those under normal oxygen conditions.
Jul 10, 2023 · For most of our tissues and cells, a lack of oxygen, or hypoxia, is bad news. Cancer cells, on the other hand, can thrive in these hypoxic conditions, which render tumors less susceptible to anti-cancer treatments, including radiation. Now, new research may offer a way to break through cancer’s hypoxia-induced defenses.
Abstract. During the last century, it has been established that regions within solid tumors experience mild to severe oxygen deprivation, due to aberrant vascular function. These hypoxic regions are associated with altered cellular metabolism, as well as increased resistance to radiation and chemotherapy. As discussed in this Timeline, over the ...
Jan 1, 2020 · Another unproven idea about oxygen and cancer is that, since many tumors thrive in oxygen-deprived (hypoxic) conditions, giving cancer cells extra oxygen might shut them down or even kill them. That’s the notion behind hyperbaric oxygen therapy — oxygen administered to a patient in a chamber under high pressure to increase its concentration in the blood, as it sometimes done to improve ...
Mar 14, 2024 · A major use of oxygen by cells is for energy production. When oxygen supplies are low, most cells can survive because they adapt, by changing which proteins they make, to produce energy through different processes than in normal oxygen levels. This is coordinated by a protein called HIF1α, which turns on the activity of genes.
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Mar 14, 2024 · Cancer treatment potential. As treatment-resistant cancer cells are likely to be deep within a tumor without access to a blood supply, and therefore oxygen, the research suggests that inhibiting ...
