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Nov 22, 2019 · A key component of the body’s oxygen-sensing system is a set of molecular hypoxia-inducible factors, or HIFs, which can respond to a need for more oxygen by turning on genes and proteins that recruit new networks of blood vessels. Cancer cells in a growing tumor can adapt to oxygen deprivation by hijacking these HIFs.
- William G. Kaelin Jr., MD
William G. Kaelin, Jr., MD, is the 2019 Nobel Prize...
- Research
Bispecific antibody therapies are a type of immunotherapy...
- Dana-Farber Staff
Uterine cancer — also known as endometrial cancer — has...
- William G. Kaelin Jr., MD
Jun 26, 2018 · Cancer cells' relationship with oxygen is a bit more complicated, and that realization has led to decades of research into whether oxygen is good for cancer or bad for it. The answers are still not definitive, but some have used the unknowns to fuel unsupported claims that certain types of oxygen therapies, including hyperbaric oxygen (HBO) therapy, can cure cancer.
Jan 1, 2020 · A key component of the body’s oxygen-sensing system is a set of molecular hypoxia-inducible factors, or HIFs, which can respond to a need for more oxygen by turning on genes and proteins that recruit new networks of blood vessels. Cancer cells in a growing tumor can adapt to oxygen deprivation by hijacking these HIFs.
Jul 10, 2023 · Oxygen in tumors is necessary for radiotherapy to effectively treat cancer, but when tumors are hypoxic, this method can fail. A new strategy for raising tumor oxygen levels entails injecting oxygen-filled bubbles into the body and using ultrasound to burst them just at the tumor site. Credit: NIH, Created with BioRender.com.
Jun 8, 2021 · Tumor cells have long been recognized as a relative contraindication to hyperbaric oxygen treatment (HBOT) since HBOT might enhance progressive cancer growth. However, in an oxygen deficit ...
- Shao-Yuan Chen, Koichi Tsuneyama, Mao-Hsiung Yen, Jiunn-Tay Lee, Jiun-Liang Chen, Shih-Ming Huang
- 2021
When tumor cells adapt to the imbalance between oxygen supply and demand, malignant features of solid tumors such as resistance to cell death, angiogenesis, and metastasis were invariably enhanced. 6,7 Emerging features of cancer development such as genome instability, the enrichment of cancer stem cells, and aberrant exosomal secretion were also suggested as hallmarks of tumor hypoxia. 8–10 ...
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Hypoxia can be broadly classified as chronic or acute . 56 Chronic hypoxia is a frequent characteristic of cancer cells residing at the limit of oxygen diffusion. 6 This diffusion-limited hypoxia occurs as tumor cells proximal to the blood vessel metabolize available oxygen, leaving the distal cells in a state of oxygen deprivation. 6, 47,57 Acute hypoxia 58 is characterized as short-term ...
