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1. www.ncbi.nlm.nih.gov › pmc › articlesValeriana officinalis L. for conscious sedation of patients ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Pharmaceutical blends containing Valerian extract have been used in a number of countries due to the lack of side-effects commonly described for benzodiazepine. Recent studies have demonstrated that Valerian offers efficacy and clinical safety in the treatment of anxiety in the medical field[ 10 ] and can restrain pharmacological reactivity in situations of psychological stress induced under ...

   • Author: Marcos Luciano Pimenta Pinheiro, Carlos Eduardo Pinto Alcântara, Márcio de Moraes, Eduardo Dias de A...
   • DOI: 10.4103/0975-7406.129176

   • Publish Year: 2014
   • Published: Apr-Jun 2014

2. ods.od.nih.gov › factsheets › ValerianValerian - Health Professional Fact Sheet

   ods.od.nih.gov › factsheets › Valerian

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   A possible mechanism by which a valerian extract may cause sedation is by increasing the amount of gamma aminobutyric acid (GABA, an inhibitory neurotransmitter) available in the synaptic cleft. Results from an in vitro study using synaptosomes suggest that a valerian extract may cause GABA to be released from brain nerve endings and then block GABA from being taken back into nerve cells [ 23 ].

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4. www.everydayhealth.com › diet-nutrition › sideSide Effects and Risks of Taking Valerian - Everyday Health

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   Nov 20, 2022 · Valerian isn’t known to interfere with sleep cycles or restful sleep, but this may not be the case if it causes insomnia. If you find yourself drowsy the next morning, it may be because your ...

5. www.sciencedirect.com › science › articleAssessment of Valeriana officinalis l. (Valerian) for ...

   www.sciencedirect.com › science › article

   Sep 1, 2019 · At higher dosages, anticonvulsive and spasmolytic effects have also been observed. 16 In clinical trials, valerian showed an important sedative-hypnotic effect at a dosage of 400 to 900 mg taken 30 to 60 minutes before bedtime. 17, 18 Unlike benzodiazepines, valerian extracts do not interfere with the voluntary coordination of movement and speech and do not cause physical and/or psychological ...

   • Author: Gustavo Jacobucci Farah, Gustavo Zanna Ferreira, Carolina Ferrairo Danieletto-Zanna, Caroline Resque...

   • Publish Year: 2019

6. draxe.com › nutrition › vValerian Root Benefits, Uses, Dosage and Side Effects - Dr. Axe

   draxe.com › nutrition › v

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   Sep 23, 2023 · Valerian contains a chemical called linarin, which has been shown to have sedative effects. Valerian extract can cause sedation by increasing your brain’s gamma-aminobutyric acid (GABA) level. GABA is an inhibitory neurotransmitter in the central nervous system. In large enough quantities it can cause a sedative effect, calming nervous activity.

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7. www.healthline.com › nutrition › valerian-root-side4 Potential Side Effects of Valerian Root - Healthline

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   Sep 23, 2024 · Valerian root may cause mild to moderate mouth and gastrointestinal effects. A 2024 research review found that several studies reported diarrhea as a side effect of valerian root. Nausea was also ...

8. People also ask

   Can valerian extract cause sedation?

   • A possible mechanism by which a valerian extract may cause sedation is by increasing the amount of gamma aminobutyric acid (GABA, an inhibitory neurotransmitter) available in the synaptic cleft.

   Valerian - Health Professional Fact Sheet - Office of Dietary

   ods.od.nih.gov/factsheets/Valerian/

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   Is valerian root a good sedative?

   • A systematic review and meta-analysis including 16 evidence-based studies indicates that valerian root is widely used and respected by the general population and physicians for its sedative effects and anti-anxiety capabilities. You may have had valerian root before and not even realized it.

   Valerian Root Benefits, Uses, Dosage and Side Effects - Dr. Axe

   draxe.com/nutrition/valerian-root/

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   What is a Valerian extract?

   • The content of volatile oils, including valerenic acids; the less volatile sesquiterpenes; or the valepotriates (esters of short-chain fatty acids) is sometimes used to standardize valerian extracts. As with most herbal preparations, many other compounds are also present. Valerian is sometimes combined with other botanicals .

   Valerian - Health Professional Fact Sheet - Office of Dietary

   ods.od.nih.gov/factsheets/Valerian/

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   Does valerian root cause headaches?

   • Although valerian root has historically been used to relieve headaches, some research found an increase in headaches after using the herb. Most of these side effects seem to happen only after long-term or high dose use. Aside from headaches, changes in mood, such as excitability and uneasiness, have also occurred.

   4 Potential Side Effects of Valerian Root - Healthline

   www.healthline.com/nutrition/valerian-root-side-effects

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   Are there any side effects of Valerian?

   • In all the clinical studies of valerian, there have been few reported serious side effects, according to the National Institutes of Health. What’s more, many of the most commonly reported side effects also occurred in people who took a placebo, or inactive pill. (1) The most common side effects associated with valerian include:

   Side Effects and Risks of Taking Valerian - Everyday Health

   www.everydayhealth.com/diet-nutrition/side-effects-risks-taking-valerian/

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9. pubmed.ncbi.nlm.nih.gov › 31158346Assessment of Valeriana officinalis l. (Valerian) for ...

   pubmed.ncbi.nlm.nih.gov › 31158346

   Conclusions: Although midazolam was more effective in reducing the physiological parameters studied, valerian seemed to provide the comfort and relaxation required, with no sedation and less somnolence than midazolam, during third molar extraction. Further studies are necessary before valerian can be clinically recommended.