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Sep 23, 2023 · Valerian contains a chemical called linarin, which has been shown to have sedative effects. Valerian extract can cause sedation by increasing your brain’s gamma-aminobutyric acid (GABA) level. GABA is an inhibitory neurotransmitter in the central nervous system. In large enough quantities it can cause a sedative effect, calming nervous activity.
In fact, a polar extract of valerian exhibited partial agonistic activity at A 1 receptors 140 and valerian contains hydrophilic constituents that interact with adenosine signaling, such as lignans of a olivil derivatives that is a partial agonist of adenosine A 1 receptors. 112,141 Thus, valerian’s hydrophilic constituents could exert the anxiolytic and sleep-inducing effects via adenosine ...
A possible mechanism by which a valerian extract may cause sedation is by increasing the amount of gamma aminobutyric acid (GABA, an inhibitory neurotransmitter) available in the synaptic cleft. Results from an in vitro study using synaptosomes suggest that a valerian extract may cause GABA to be released from brain nerve endings and then block GABA from being taken back into nerve cells [ 23 ].
Several different species of Valeriana have been used for sedation and sleep in many different cultures throughout the world, including V. wallichii in India and V. angustifolia in China and Japan. 7 Also, several studies have shown that components of valerian inhibit the breakdown of gamma-aminobutyric acid in the brain and induce sedation and a decrease in central nervous system activity in ...
Valerian might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking valerian with sedative medications might cause ...
Nov 20, 2022 · Alcohol is a depressant that can have a sedative effect in some people, which may be increased when combined with valerian. Don’t drink alcohol if you take valerian during the day, unless you ...
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Sep 18, 2023 · However, it will likely cause sedation. Some people feel a " hangover " after taking valerian. It may also cause headaches, upset stomach , uneasiness, irregular heartbeat, or other symptoms ...
