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  1. Apr 17, 2023 · Studies that included adults with any mood or anxiety disorder treated with a low carbohydrate or ketogenic intervention, reporting effects on mood or anxiety symptoms were eligible for inclusion.

  2. Mar 15, 2023 · Although our analysis on eight studies indicated no significant effect of the low carbohydrate diet on depression and anxiety, the results of the subgroup analysis indicated that the low carbohydrate diet increase anxiety in the Australia region, and in studies with <26 % carbohydrate intake.

    • Improve blood glucose control. The higher your blood sugar, the higher your brain sugar . . . so every time your blood sugar spikes to unhealthy highs, you’re flooding your brain tissue with excess glucose.
    • Lower blood insulin levels. Persistently or repeatedly high insulin levels can cause the insulin receptors on the surface of the blood-brain barrier to become insulin-resistant, meaning they can become damaged, desensitized, and dwindle in number.
    • Reduce inflammation. High-sugar diets promote excessive, unnecessary inflammation inside the brain, triggering the release of various inflammatory cytokines—tiny SOS signals that recruit first-responder cells to the scene.
    • Boost antioxidant defenses. High-sugar diets cause excessive, unnecessary oxidative damage. Flooding cells with too much glucose all at once leads to a spilling over of oxygen free radicals, which are normally mopped up by our own natural, internal antioxidant molecules (such as glutathione).
  3. One proposed dietary approach is carbohydrate reduction (typ-ically with moderate increases in fat and protein), in the form of low carbohydrate (<130 g carbohydrate/day) and very low carbohydrate (<25–50 g/day) ketogenic diets. These have been defined and oper-ationalised (Table 1).

  4. Apr 17, 2023 · One report described a participant with panic disorder (n = 1) 60 on a ketogenic diet who experienced negative effects (internal ‘shakiness’, increase in anxiety and recurrence of panic attacks, despite increasing sertraline dose). These symptoms resolved on discontinuation of the ketogenic diet.

  5. Mar 15, 2023 · Several studies have evaluated the effect of a low carbohydrate diet on mood and mental disorders such as depression and anxiety so far. The results of these studies are contradictory. Some studies have shown a protective effect of low carbohydrate diet (Campbell and Campbell, 2019a; Phelps et al., 2013a; Ren et al., 2020), but others had no ...

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  7. Apr 17, 2023 · There was some evidence for efficacy of ketogenic diets in those with bipolar disorder, schizoaffective disorder and possibly unipolar depression/anxiety. Relapse after discontinuation of the diet was reported in some individuals.

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