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Nov 22, 2019 · “Exposure to air will not make tumors grow faster or cause cancer to spread to other parts of the body,” the National Cancer Institute says. Hyperbaric oxygen therapy for cancer. Another unproven idea about oxygen and cancer is that, since many tumors thrive in oxygen-deprived (hypoxic) conditions, giving cancer cells extra oxygen might ...
- William G. Kaelin Jr., MD
The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing...
- Research
Bispecific antibody therapies are a type of immunotherapy...
- Dana-Farber Staff
Uterine cancer — also known as endometrial cancer — has...
- William G. Kaelin Jr., MD
Pre-clinical studies in mice 12 demonstrated that even tumors as small as 0.6 mm 3 may contain areas of hypoxia that are resistant to radiation treatment, and that such resistance could be mitigated by oxygen breathing prior to tumor irradiation. 13 Indeed, it is now well-established that hypoxia is a common feature of most, if not all, experimental solid tumors, and that there exists a direct ...
Jul 10, 2023 · Oxygen in tumors is necessary for radiotherapy to effectively treat cancer, but when tumors are hypoxic, this method can fail. A new strategy for raising tumor oxygen levels entails injecting oxygen-filled bubbles into the body and using ultrasound to burst them just at the tumor site. Credit: NIH, Created with BioRender.com.
When tumor cells adapt to the imbalance between oxygen supply and demand, malignant features of solid tumors such as resistance to cell death, angiogenesis, and metastasis were invariably enhanced. 6,7 Emerging features of cancer development such as genome instability, the enrichment of cancer stem cells, and aberrant exosomal secretion were also suggested as hallmarks of tumor hypoxia. 8–10 ...
Oct 27, 2020 · Hypoxia is also likely to be a treatment-limiting factor in the most prevalent paediatric cancers, such as leukaemia, brain cancer and sarcomas: for instance, chemoresistance was demonstrated to ...
- Carolina Bernauer, Y. K. Stella Man, Julia C. Chisholm, Julia C. Chisholm, Elise Y. Lepicard, Simon ...
- 2021
Mar 14, 2024 · News. Researchers at the Francis Crick Institute have shed light on how cancer cells survive in the first few hours after being cut off from a supply of oxygen. Published today in The EMBO Journal, this finding could one day help to prevent cancer from becoming resistant to therapy. A major use of oxygen by cells is for energy production.
A critical consequence of the inadequate vascular networks in solid tumors is the development of regions of hypoxia [low oxygen tensions typically defined as oxygen tensions (pO 2 values) < 10 mm Hg]. Tumor cells existing in such hypoxic environments have long been known to be resistant to anticancer therapy, display an aggressive phenotype ...
