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  1. Mar 31, 2023 · Evidence suggests that if appropriate for an individual patient, the dietary or supplemented intake of other nutrients, such as those listed below, may be protective against depression development risk or reduce depressive symptoms: Vitamin K 16. Zinc (postpartum depression) 17. Magnesium 18,19. B vitamins 20.

  2. Nov 29, 2021 · a mood stabilizer such as lithium. a benzodiazepine. psychotherapy. thyroid hormone. Electroconvulsive therapy (ECT) a nutraceutical such as omega-3 fatty acids. a medical food such as L-methylfolate (more on this below) Other potential adjunct agents currently under investigation include stimulants, opiate modulators, dopamine agonists ...

  3. Aug 6, 2024 · In the United States, major depression ranks second among all diseases and injuries as a cause of disability, and persistent depressive disorder (dysthymia) ranks 20 th [3,4]. In addition, major depression is often recurrent. More than 40 percent of patients who recover from an initial episode will experience a recurrence within two years.

  4. Nov 2, 2023 · Efficacy of second-generation antipsychotics – Multiple trials have demonstrated that adjunctive treatment with different second-generation antipsychotics can be efficacious for unipolar, nonpsychotic major depression that has not responded to antidepressant monotherapy [14,49,54,64-66]. However, adverse effects and discontinuation of ...

  5. The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled study. J. Clin. Psychiatry 68, 843–853. [Google Scholar] Browne M, Lapierre Y, Hrdina P, et al. , 1990. Lithium as an adjunct in the treatment of major depression. Int. Clin.

  6. APA's Clinical Practice Guideline recommends seven psychotherapy interventions as well as a second-generation antidepressant (selective serotonin reuptake inhibitors—SSRIs—serotonin-norepinephrine reuptake inhibitors—SNRIs—or norepinephrine/dopamine reuptake inhibitors—NDRIs) for the treatment of depression in adults.

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  8. Although it has been suggested that antidepressants may be less effective in anxious depression (Fava et al 2008) and that tricyclics may be less effective in atypical depression, adjunctive aripiprazole showed significantly greater efficacy than placebo in patients with anxious depression (defined by a total score of ≥7 on the anxious/somatization factor of the HAM-D17) or atypical ...

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