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Jan 21, 2023 · How the brain conjures conscious awareness from the electrical activity of billions of individual nerve cells remains one of the great unanswered questions of life. Each of us knows that we are ...
Genomic mosaicism describes the phenomenon where some but not all cells within a tissue harbor unique genetic mutations. Traditionally, research focused on the impact of genomic mosaicism on clinical phenotype—motivated by its involvement in cancers and overgrowth syndromes. More recently, we increasingly shifted towards the plethora of neutral mosaic variants that can act as recorders of ...
Mar 23, 2022 · Genetic mosaicism is the result of the accumulation of somatic mutations in the human genome starting from the first postzygotic cell generation and continuing throughout the whole life of an ...
Figure 1. Open in a new tab. Superior pattern processing (SPP) capabilities of the human brain evolved in association with expansion of the cerebral cortex. A comparison of the gross anatomy of the brains of humans and chimpanzees (Pan troglodytes) reveals considerable expansion of three regions in humans, the prefrontal cortex, the visual ...
- The links between neurons are called synapses. What exactly is a synapse, and what happens there? It’s basically a connection: one cell talking to another.
- You’ve been studying synapses for more than two decades. How has our understanding evolved? When I started, we didn’t know anything about how synapses form.
- In a developing fetus or a baby, neurons have been thought to form lots of connections willy-nilly, as described by the delightful phrase “exuberant synaptogenesis.”
- The ability of the brain to strengthen or weaken synapses depending on how active they are is often referred to as “plasticity.” What is plasticity and why is it important?
gnomic. Expressed in or of the nature of short, pithy maxims or aphorisms. Recorded from the early 19th century (gnomical in the same sense dates from the early 16th century), the word comes from Greek gnōmikos, ultimately formed as English gnome (late 16th century), ‘thought, judgement, opinion’, from Greek gnōme in same sense, from ...
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Genomic imprinting is a process of silencing genes through DNA methylation. The repressed allele is methylated, while the active allele is unmethylated. This stamping process, called methylation, is a chemical reaction that attaches small molecules called methyl groups to certain segments of DNA [3].
