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Dec 1, 2016 · Abstract. Historical analysis of studying chromosome changes in evolution allows better understanding of the current level of research in this area. Reorganizations of the genetic system due to ...
Jun 14, 2022 · Structural chromosomal rearrangements result from different mechanisms of formation, usually related to certain genomic architectural features that may lead to genetic instability. Most of these rearrangements arise from recombination, repair, or replication mechanisms that occur after a double-strand break or the stalling/breakage of a replication fork. Here, we review the mechanisms of ...
Apr 17, 2012 · 2. Recombinations. Genetic recombination is a process that is catalyzed by many different enzymes called as recombinases. It can take place in all living cells from bacteria to eukaryota as well as viral genomes. This process mainly results in DNA repair, genomic rearrangements, variations and evolutional forces.
- Özlem Barış, Mehmet Karadayı, Derya Yanmış, Medine Güllüce
- 2013
The study of rearrangement mechanisms obviously benefits from the development of new techniques to observe the rearrangements and breakpoints with a higher resolution. In the past, fluorescence in situ hybridization (FISH) has defined the duplications and deletions with resolution to about one BAC clone (150 to 200 kb) and accelerated the discovery of NAHR and NHEJ mechanisms.
Aug 1, 2010 · the mechanism approach. The first part discusses the idea of mechanistic explanation from. the point of view of philosophy of science and relates it to causation and to the covering-law. account ...
Gene Rearrangement. In subject area: Biochemistry, Genetics and Molecular Biology. Class switch recombination is the gene rearrangement process by which our B lymphocytes change from IgM production to IgG, IgA, or IgE. Unlike the well-characterized V (D)J recombination, the mechanism of class switch recombination has been largely enigmatic ...
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Abstract. Mechanisms are ubiquitous in sociological explanation. Recent theoretical work has sought to extend mechanistic explanation further still: into cultural and interpretative analysis. Yet it is not clear that the concept of “mechanism” can coherently unify interpretation and causal explanation within a single explanatory framework.
