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Study with Quizlet and memorize flashcards containing terms like 4 Types of Gene Rearrangements, Homologous Recombination, Holliday Model Heteroduplex DNA and more.
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Study with Quizlet and memorize flashcards containing terms like what are the key differences between prokaryotes and eukaryotes?, what are the two main roles of chromatin?, define nucleosome and more.
Dec 30, 2022 · (A) rearrangement of α chain and (B) β chain (C) protein structure of TCR. The enzyme that produces this diversity is a complex called the V(D)J recombinase. The recombination occurs in two parts: first double-stranded breaks are made at re- combination signal sequence (RSS) sites, then the breaks are repaired by the general double-stranded break repair mechanism.
Oct 31, 2023 · Figure 13.2B. 1 13.2 B. 1: Inversion heterozygotes: When one chromosome undergoes an inversion, but the other does not, one chromosome must form an inverted loop to retain point-for-point interaction during synapsis. This inversion pairing is essential to maintaining gene alignment during meiosis and to allow for recombination.
Like other programmed gene rearrangements, however, gene amplification is a relatively infrequent event that occurs in highly specialized cell types; it is not a common mechanism of gene regulation. Gene amplification also occurs as an abnormal event in cancer cells, where it results in the increased expression of genes that contribute to uncontrolled cell growth.
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Genome rearrangements refer to large-scale changes in the structure of an organism's DNA, which can include deletions, duplications, inversions, and translocations of chromosomal segments. These rearrangements can impact gene expression and contribute to genetic diversity, evolution, and various diseases, making them a crucial area of study within genomics and bioinformatics.
