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Dec 1, 2021 · Polycomb repressive complexes represent a paradigm of chromatin-based gene regulation in animals. The Polycomb repressive system comprises two central protein complexes, Polycomb repressive complex 1 (PRC1) and PRC2, which are essential for normal gene regulation and development.
- Neil P. Blackledge, Robert J. Klose
- 10.1038/s41580-021-00398-y
- 2021
- 2021/12/12
Jan 1, 2020 · Repressive interactions play a critical role in these networks, facilitating decision-making between two or more alternative cell fates. Here, we use the ventral neural tube as an example to illustrate how cross repressive interactions within a network drive pattern formation and specify cell types in response to a graded patterning signal.
- M. Joaquina Delás, James Briscoe
- 2020
Sep 14, 2010 · Here we summarize conserved pathways for transcriptional repression prevalent throughout all forms of life, as well as indirect mechanisms that appear to have originated in eukaryotes, consistent with the unique chromatin environment of eukaryotic genes.
- Sandhya Payankaulam, Li M. Li, David N. Arnosti
- 2010
Feb 1, 2013 · Repressive complexes may function in a variety of ways at active sites in the genome but one overriding theme could explain their presence, even if their mode of action differs depending on circumstance: the genes decorated by these complexes are those for which responsiveness is crucial.
- Nicola Reynolds, Aoife O'Shaughnessy, Brian Hendrich
- 2013
Aug 8, 2019 · Yet all of the mutations have something in common: they affect repressive interactions between genes. To survey the depth of this relationship between gene repression and metabolism, we eliminated an entire family of regulatory repressors that control all stages of Drosophila development.
- Justin J. Cassidy, Sebastian M. Bernasek, Rachael Bakker, Ritika Giri, Nicolás Peláez, Nicolás Peláe...
- 10.1016/j.cell.2019.06.023
- 2019
- 2019/08/08
Dec 7, 2017 · Why would a cell transcribe mRNAs that cannot produce protein? Why would a cell repress gene promoters by distal transcription of mRNA isoforms? Although the “why” questions are extremely difficult to answer in biology, we will describe our perspective on the logic of this gene repression mechanism.
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What is transcriptional repression?
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Nov 24, 1999 · Repression. Targeting the Heart of the Matter. Transcriptional repression is an essential mechanism in the precise control of gene expression. Nearly 40 years ago, Jacob and Monod recognized the importance of transcriptional repressor molecules in the regulation of gene expression in bacteria.
