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Uncoupling proteins (UCPs) comprise a complex of three homologous isoforms (UCP 1, 2, 3) that inhibit the synthesis of ATP following oxidative phosphorylation by dissipating energy as heat and by reducing the mitochondrial membrane potential. UCP1 is solely expressed in brown adipose tissue, which is of low abundance in humans, whereas UCP2 and ...
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Abstract. The uncoupling protein (UCP1) is a proton (H+) transporter in the mitochondrial inner membrane. By dissipating the electrochemical H + gradient, UCP1 uncouples respiration from ATP synthesis, which drives an increase in substrate oxidation via the TCA cycle flux that generates more heat.
Abstract. Initially, the term uncoupling was introduced to define the respiration processes proceeding without phosphorylation. Such a phenomenon was discovered by Belitser and Tsibakova in 1939. The authors found that the addition of arsenate to a skeletal muscle mince allowed respiration to occur without ATP formation (Belitser and Tsibakova ...
- Vladimir P. Skulachev
- 1999
Aug 8, 2021 · Abstract. There has been an explosion of interest in the use of uncouplers of oxidative phosphorylation in mitochondria in the treatment of several pathologies, including neurological ones. In this review, we analyzed all the mechanisms associated with mitochondrial uncoupling and the metabolic and signaling cascades triggered by uncouplers.
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Uncoupling means that there is a dissociation between the proton electrochemical gradient across the inner mitochondrial membrane and the synthesis of ATP.During the uncoupling process, protons tend to leak back across the inner membrane, which dissipates and decreases the overall stored energy as heat instead of being coupled and used for the production of ATP.
