Search results
Dec 9, 2020 · Stiff-person syndrome (SPS) is a rare and disabling central nervous system disorder with no satisfactory treatment. Muscle rigidity, sporadic muscle spasms, and chronic muscle pain characterize SPS. SPS is strongly correlated with autoimmune diseases, and it is usual to find high titers of antibodies against acid decarboxylase (GAD65).
- Open in a Separate Window
Stiff-person syndrome (SPS) is a rare and disabling central...
- Table
He took levetiracetam 500 mg bd, gabapentin 1,200 mg tds,...
- PMC Free Article
Therapeutic Intervention. Following the clinical...
- Open in a Separate Window
May 21, 2024 · Stiff-person syndrome (SPS, formerly called stiff-man syndrome) is an uncommon disorder characterized by progressive muscle stiffness, rigidity, and spasm involving the axial muscles, resulting in severely impaired ambulation [1,2].
Apr 14, 2023 · The therapies in SPS are aimed at the 2 main pathogenic mechanisms: (1) impaired reciprocal GABAergic inhibition, the key neurophysiologic dysfunction causing stiffness and spasms, that justifies the need for GABA-enhancing therapies, 2, 4 and (2) autoimmunity, based on SPS autoimmune pathogenesis, that justifies the application of immunotherapi...
- Marinos C. Dalakas
- 2023/05
- 10.1212/NXI.0000000000200109
- What Is Stiff Person Syndrome?
- Stiff Person Syndrome Symptoms
- Types of Stiff Person Syndrome
- What Causes Stiff Person Syndrome?
- Stiff Person Syndrome Diagnosis
- Stiff Person Syndrome Treatment
Stiff person syndrome is a rare autoimmune neurological disorder that most commonly causes muscle stiffness and painful spasms that come and go and can worsen over time. However, some people experience other symptoms such as an unsteady gait, double vision or slurred speech. SPS symptoms are thought to be related to which type of SPS a person has. ...
Stiff person syndrome most often causes painful muscle contractions and spasms that often begin in the legs and back. Spasms can also affect the abdomen, and less often the upper trunk, arms, neck and face. The spasms can occur in episodes, especially when a person with SPS is surprised or startled, or moves suddenly. Cold temperatures and emotiona...
Classic Stiff Person Syndrome
Most people with SPS have the classic form. Symptoms include stiffness and spasms in the muscles of the lower back, legs (more than arms) and sometimes abdomen. People with classic SPS may have frequent muscle spasms and walk with a stiff gait, and they can be in pain most of the day.
Partial Stiff Person Syndrome
Less commonly, people with SPS can have partial SPS, sometimes called stiff limb syndrome, stiff leg syndrome or stiff trunk syndrome. With partial SPS, tight muscles and spasms are limited to a specific area, usually one leg. For most people with partial SPS, spasms and contractions do not affect the trunk but, in some cases, they affect part of the chest or abdomen.
Stiff Person Syndrome Plus
Another less common type of the syndrome is SPS plus, which is best described as a combination of classic features (spasms and stiffness) and symptoms that suggest brainstem and/or cerebellar dysfunction. People with SPS plus can have muscle spasms and rigidity along with lack of coordination, double vision, slurred speech and other symptoms.
Much needs to be learned about how stiff person syndrome develops. It is believed to be an autoimmune disorder— in autoimmune conditions, the body’s immune system attacks healthy tissues. Similar to other autoimmune conditions, SPS affects more women than men. Most people with stiff person syndrome have unique antibodies in their blood that are mad...
Stiff person syndrome is very rare and complex, and its many symptoms can be caused by other, more common conditions. It may take time and several tests to diagnose SPS. If your doctor suspects that your symptoms are due to stiff person syndrome, he or she will review your detailed medical history and perform a physical exam followed by a diagnosti...
Stiff person syndrome is a complex condition that affects people in different ways. Also, different types of SPS may require different treatment approaches. A personalized SPS treatment plan typically addresses the syndrome’s autoimmune, neurologic, visual, mobility and pain aspects. Although currently, no therapy makes stiff person syndrome go awa...
Jul 10, 2023 · Describe the clinical presentation and diagnostic criteria of stiff person syndrome (SPS). Summarize the management options for stiff person syndrome (SPS). Outline the importance of early recognition of patients with stiff person syndrome (SPS) and an interprofessional approach to improve outcomes.
- Alexandra Muranova, Elena Shanina
- 2023/07/10
- 2021
Stiff-person syndrome (SPS) is an autoimmune neuromuscular disorder characterized by severe and progressive rigidity, stiffness of truncal and proximal muscles, and painful muscle spasms. 1. Etiology and Pathophysiology.
Sep 3, 2024 · Stiff-person syndrome (SPS) is the most common form of glutamic acid decarboxylase (GAD) antibody spectrum disorder; others include cerebellar ataxia, encephalitis and autoimmune epilepsy.
