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Aug 18, 2021 · Microtubule dynamics and their control are essential for the normal function and division of all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic microtubule ...
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Aug 14, 2020 · Tubulin PTMs can modulate MT dynamics directly or indirectly by influencing the interactions between MTs and microtubule-interacting proteins (which can stabilize, destabilize, or cut microtubules). While for the vast majority of modifying enzymes, a tubulin heterodimer already incorporated into the microtubule lattice is a preferred substrate, in some cases, free tubulin heterodimers are ...
- Filip Borys, Filip Borys, Ewa Joachimiak, Hanna Krawczyk, Hanna Fabczak
- 10.3390/molecules25163705
- 2020
- Molecules. 2020 Aug; 25(16): 3705.
Apr 19, 2018 · The conformational cycle of tubulin is directly linked to microtubule dynamics. Microtubule dynamics also depend on the size and composition of the stabilizing cap, loss of which leads to ...
- Gary J. Brouhard, Luke M. Rice
- 2018
Apr 22, 2016 · The question that most intrigues me now is the length control problem: what sets the size of microtubules and microtubule-based structures. How do small molecules like tubulin, motors and MAPs ...
- Gary Borisy, Rebecca Heald, Jonathon Howard, Carsten Janke, Andrea Musacchio, Eva Nogales
- 2016
Second, although the walls of microtubules are often represented as being solid, high-resolution structural analysis shows that microtubule walls contain holes large enough to allow diffusion of water and small molecules such as taxol (Li et al. 2002). The inside of a microtubule is an intriguing space that is, as yet, relatively unexplored in terms of its significance and potential interactions.
- Holly V. Goodson, Erin M. Jonasson
- 10.1101/cshperspect.a022608
- 2018
- 2018/06
Sep 9, 2020 · Interestingly, similar to doublecortin, EB proteins bind at the corner of four tubulin heterodimers, but they interfere with microtubule dynamics in a different manner. Although a mild increase of microtubule growth has been measured in in vitro experiments, the most obvious effect of EBs is to enhance catastrophe frequency, making microtubules more dynamic ( Duellberg et al., 2013 ).
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May 24, 2021 · In addition to exerting their influence at microtubule ends, regulatory proteins can also affect microtubule structure and dynamics through interactions with the microtubule lattice. Tubulin subunits can be removed from the lattice by physical perturbations, such as bending 46–48 , or by chemomechanical forces exerted by microtubule-severing proteins such as spastin and katanin 99–102 .
