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      • Advances in clinical research and diagnostic testing methods over the last 3 decades suggest that an update for existing definitions and approaches for fever and inflammation of unknown origin is needed [1–4]. Classic fever of unknown origin (FUO) was first robustly studied in 1961, with subsequent modifications in definitions (Table 1) [1, 2].
      academic.oup.com/ofid/article/11/7/ofae298/7689389
  1. Nov 28, 2023 · Clinicians commonly refer to a febrile illness without an initially obvious etiology as fever of unknown origin (FUO). However, most febrile illnesses either resolve before a diagnosis can be made or develop distinguishing characteristics that lead to a diagnosis.

  2. Clinicians commonly refer to a febrile illness without an initially obvious etiology (sometimes called fever without localizing signs) as fever of unknown origin (FUO). This usage is not accurate. Most febrile illnesses either resolve before a diagnosis can be made or develop distinguishing characteristics that lead to a diagnosis.

  3. Nov 20, 2023 · This topic discusses etiologies of classic fever or unknown origin. Other categories of FUO, not discussed in this topic, include health care-associated FUO, FUO in immunocompromised patients, and travel-associated FUO.

  4. Jun 10, 2024 · Classic fever of unknown origin (FUO) was first robustly studied in 1961, with subsequent modifications in definitions [1, 2]. These FUO definitions require an illness of ≥3 weeks duration and temperatures of ≥38.3°C (≥100.9°F) on several occasions [1, 2].

  5. Aug 14, 2023 · There is no clear-cut diagnostic approach to fever of unknown origin (FUO). Thorough history with a focus on the most probable etiology based on the patient’s symptoms is the key to pinpoint the origin of FUO.

    • Ilona Brown, Nancy A. Finnigan
    • 2023/08/14
    • 2021
  6. Feb 2, 2022 · In 1961, Petersdorf and Beeson defined fever of unknown origin (FUO) as a temperature of 38.3°C or higher for at least 3 weeks without a diagnosis, despite 1 week of inpatient investigations....

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  8. Fever of unknown origin is defined as a clinically documented temperature of 101°F or higher on several occasions, coupled with an unrevealing diagnostic workup. The differential diagnosis is...

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