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Jan 26, 2024 · Abstract The activity of many physiological mechanisms depends on pH; therefore, maintaining a normal pH in the body is one of the important tasks of homeostatic regulation. Shifts in the acid–base balance can be associated with both pathological and physiological processes. Physiological acidosis in skeletal muscles appears due to physical exercise as muscle contractions may significantly ...
In conclusion, acetyl choline-induced augmented vasorelaxation under acidosis is mediated by NOS-NO-cGMP, with a partial role of MEGJ as EDH mediators in the SMA. Present data suggest a novel role of connexin as therapeutic targets to attenuate the detrimental effect of acidosis on vascular tone.
Acid-basis homeostasis is an important physiologic parameter that controls cell function, and changes in pH can influence vascular tone by regulating endothelium and vascular smooth muscle cells. This review presents a current perspective of the effects of intracellular acidosis on the function and the basic regulatory mechanisms of endothelial ...
- Ettore Crimi, Fabio Silvio Taccone, Teresa Infante, Sabino Scolletta, Valeria Crudele, Claudio Napol...
- 2012
Endothelial cells are located on the intima – which is the inner lining of the vasculature and they control vascular function by responding to various hormones, neurotransmitters and vasoactive factors which affect vasomotion, thrombosis, platelet aggregation and inflammation . The balanced production of these vasoactive factors is atheroprotective, whereas a damaged endothelium causes ...
Jul 25, 2014 · Acidosis always reduced myogenic tone at transmural pressures between 20 and 120 mmHg. Acidification at a transmural pressure of 40 mmHg caused an increase in diameter and a decrease in [Ca 2+] i. This was also seen in the presence of l ‐NNA and after depolarization with 50 mM K +. The response to hypercapnic and normocapnic acidosis was similar.
- H.-L. Peng, A. Ivarsen, H. Nilsson, C. Aalkjaer
- 1998
Oct 6, 2017 · When arteries are exposed to extracellular acid–base disturbances, the intracellular environment of the cells of the vascular wall is affected to varying degrees: typically, the change in VSMC pH i in rat and mouse resistance arteries is up to 70% of the change in pH o when exposed to respiratory acidosis caused by elevated pCO 2 and around 50% when exposed to metabolic acidosis accompanied ...
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The Effect of Extracellular Acidosis on Vascular Tone In many organs, a decrease in extracellular pH is accompanied by a decrease in vascular tone: with aci-dosis, there is a decrease in vasoconstrictor and/or an increase in vasodilator responses. Such changes in − HCO 3 − HCO 3 − HCO 3 tone were shown for isolated arteries and arterioles of
