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  1. Feb 13, 2024 · A new study by scientists at Brown University reveals the mechanisms by which Agent Orange affects the brain and how those processes can lead to neurodegenerative diseases. The research shows that exposures to Agent Orange herbicidal chemicals damage frontal lobe brain tissue of laboratory rats with molecular and biochemical abnormalities that are similar to those found in early-stage ...

  2. Feb 14, 2024 · A new study by scientists at Brown University reveals the mechanisms by which Agent Orange affects the brain and how those processes can lead to neurodegenerative diseases. The research shows that ...

  3. Feb 2, 2024 · Furthermore, critical reviews and literature analyses revealed links between Agent Orange exposures and later development of peripheral nervous system or central nervous system (CNS) degenerative diseases , and significantly higher rates and earlier onsets of dementia . Although causal roles have been difficult to prove due to overlap with anticipated aging-associated pathologies, their higher ...

  4. Nov 15, 2018 · This chapter considers the possible effects of toxic exposure to the herbicides used during the Vietnam War and specific clinical conditions associated with the central nervous system (CNS) and the peripheral nervous system (PNS), primarily brain dysfunctions. The COIs are 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram (4-amino-3,5,6 ...

    • 2018/11/15
  5. Jan 25, 2021 · Although evidence of an association between Agent Orange exposure and dementia was considered insufficient, dementia is a growing concern among veterans (a 20% increase by 2033), with military-relevant conditions found to be particularly salient risk factors (eg, posttraumatic stress disorder [PTSD], traumatic brain injury). 3,4,5,6 The goal of this study was to examine the association between ...

    • Steven Martinez, Kristine Yaffe, Yixia Li, Amy L. Byers, Amy L. Byers, Carrie B. Peltz, Deborah E. B...
    • 10.1001/jamaneurol.2020.5011
    • 2021
    • JAMA Neurol. 2021 Apr; 78(4): 473-477.
  6. Feb 14, 2024 · A new study by scientists at Brown University reveals the mechanisms by which Agent Orange affects the brain and how those processes can lead to neurodegenerative diseases. The research shows that ...

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  8. Mar 6, 2014 · In addition, TCDD has been shown to affect phosphokinase C biochemistry in nerve cells and so could affect the integrity and physiology of nerve cells (Kim et al., 2007; Lee et al., 2007). Cytochrome P450 1A1, the aryl hydrocarbon receptor (AHR), and the AHR nuclear transporter occur in the brain, so TCDD might be likely to exert effects in the brain ( Huang et al., 2000 ).

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