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Jan 27, 2023 · Allison, a Nobel laureate whose research led to the discovery of the T-cell antigen receptor and the anti CTLA-4 antibody ipilimumab, and director of James P. Allison Institute, Regental Chair of Immunology, and vice president of immunobiology at MD Anderson Cancer Center, said to The Cancer Letter. Allison is also the Olga Keith Wiess Distinguished University Chair for Cancer Research and ...
Apr 18, 2014 · James Allison, Ph.D., knows his T cells. For the past 30 years, he's studied them inside and out, learning what makes them run and hum. From his laboratory have emerged some of the most important discoveries in immunology. In the early 1980s, Allison was one of the first to identify the T cell receptor—the part of a T cell that binds to ...
The idea of using the immune system to fight cancer has been around for decades, with multiple false starts along the way. The field of cancer immunotherapy had largely been focused entirely on ways in which to turn T cells on, with implementation of therapies such as cytokines, for example IL-2, or antigenic vaccines.
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Apr 18, 2014 · The Texas T Cell Mechanic. James Allison, PhD, knows his T cells. For the past 30 years, he’s studied them inside and out, learning what makes them run and hum. From his laboratory have emerged some of the most important discoveries in immunology. In the early 1980s, Allison was one of the first to identify the T cell receptor—the part of a ...
In 1982, Allison first discovered the T-cell receptor. [20] Allison's research to elucidate mechanisms of T-cell responses was conducted in the 1990s at the University of California, Berkeley. [21] [22] In the early 1990s, James Allison showed that CTLA-4 acts as an inhibitory molecule to restrict T-cell responses.
James P. Allison in the lab. Photo: The University of Texas MD Anderson Cancer Center. T cells can identify dangers by using a protein on their surface called the T cell receptor that binds to invaders and triggers the immune system to fight them. Additional proteins acting as T-cell accelerators are also required to trigger a full-blown immune ...
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Dr. Allison has spent a distinguished career studying the regulation of T cell responses and developing strategies for cancer immunotherapy. He earned the 2018 Nobel Prize in Physiology or Medicine, which he shared with Dr. Tasuku Honjo, “for their discovery of cancer therapy by inhibition of negative immune regulation.”.
