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Jan 27, 2023 · Allison, a Nobel laureate whose research led to the discovery of the T-cell antigen receptor and the anti CTLA-4 antibody ipilimumab, and director of James P. Allison Institute, Regental Chair of Immunology, and vice president of immunobiology at MD Anderson Cancer Center, said to The Cancer Letter. Allison is also the Olga Keith Wiess Distinguished University Chair for Cancer Research and ...
Additional proteins acting as T-cell accelerators are also required to trigger a full-blown immune response. During the 1990s, Allison studied a protein on the surface of T cells called CTLA-4. He was one of several scientists who observed that CTLA-4 functions as a brake on T cells, preventing them from attacking invaders, and thus also regulating the immune cells to avoid them attacking our ...
The idea of using the immune system to fight cancer has been around for decades, with multiple false starts along the way. The field of cancer immunotherapy had largely been focused entirely on ways in which to turn T cells on, with implementation of therapies such as cytokines, for example IL-2, or antigenic vaccines.
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Apr 18, 2014 · The Texas T Cell Mechanic. James Allison, PhD, knows his T cells. For the past 30 years, he’s studied them inside and out, learning what makes them run and hum. From his laboratory have emerged some of the most important discoveries in immunology. In the early 1980s, Allison was one of the first to identify the T cell receptor—the part of a ...
Apr 18, 2014 · James Allison, Ph.D., knows his T cells. For the past 30 years, he's studied them inside and out, learning what makes them run and hum. From his laboratory have emerged some of the most important discoveries in immunology. In the early 1980s, Allison was one of the first to identify the T cell receptor—the part of a T cell that binds to ...
Early life, South Texas. I was born in 1948 in Alice, a small farming and oil town in the brush country of the Rio Grande Valley in South Texas. Those early years in Alice shaped who I would later become. Being in Texas, the whole town, including my two older brothers, was obsessed with football.
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In his first major finding, at Smithville, Allison identifies the protein structure of the T-cell receptor, the previously mysterious ignition switch for immune response, with papers in the Journal of Immunology and Cell. 1984 Allison is recruited by the University of California, Berkeley, to lead its immunology department. 1992 At Berkeley ...
