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Apr 13, 2022 · Abstract. Antigen processing and presentation are the cornerstones of adaptive immunity. B cells cannot generate high-affinity antibodies without T cell help. CD4 + T cells, which provide...
Jun 15, 2007 · During differentiation, apoptosis ensures that lymphocytes express functional antigen receptors and is essential for eliminating lymphocytes with dangerous self-reactive specificities.
- J T Opferman
- joseph.opferman@stjude.org
- 2008
1-5. Most infectious agents induce inflammatory responses by activating innate immunity. Microorganisms such as bacteria that penetrate the epithelial surfaces of the body for the first time are met immediately by cells and molecules that can mount an innate immune response.
- Charles A Janeway, Paul Travers, Mark Walport, Mark J Shlomchik
- 2001
- 2001
Oct 15, 2016 · Cell signaling pathways regulate much in the life of a cell: from shuttling cargo through intracellular compartments and onto the cell surface, how it should respond to stress, protecting itself from harm (environmental insults or infections), to ultimately, death by apoptosis.
These examples illustrate how the ITIM motif is able to modify signals originating from the B-cell receptor, the T-cell receptor, Fc receptors, and NK cell receptors, even to the extent of completely negating them.
- Charles A Janeway, Paul Travers, Mark Walport, Mark J Shlomchik
- 2001
- 2001
There are two types of adaptive responses: the cell-mediated immune response, which is controlled by activated T cells, and the humoral immune response, which is controlled by activated B cells and antibodies.
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Aug 31, 2023 · The body develops immunologic tolerance to these self antigens by triggering apoptosis in self-reactive lymphocytes. Alternately, immature B-lymphocytes with self-reactive B-cell receptors may be stimulated to undergo a new gene rearrangement to make a new receptor that is no longer self-reactive. This process is called receptor editing.
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