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Jun 15, 2007 · Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2,...
- J T Opferman
- joseph.opferman@stjude.org
- 2008
Apr 13, 2022 · Antigen processing and presentation are the cornerstones of adaptive immunity. B cells cannot generate high-affinity antibodies without T cell help. CD4+ T cells, which provide such help,...
- Novalia Pishesha
Aug 31, 2023 · Naive T8-lymphocytes have T cell receptors (TCRs) that, in cooperation with CD8 molecules, bind to MHC-I molecules with attached epitope from an antigen found on the surface of antigen-presenting dendritic cells. Most proteins are T-dependent antigens.
Oct 15, 2016 · Cell signaling pathways regulate much in the life of a cell: from shuttling cargo through intracellular compartments and onto the cell surface, how it should respond to stress, protecting itself from harm (environmental insults or infections), to ultimately, death by apoptosis.
Lymphocytes |. Mast Cells |. Natural Killer (NK) Cells |. Polymorphonuclear Leukocytes. The immune system consists of cellular components and molecular components that work together to destroy antigens. (See also Overview of the Immune System.) Antigen-Presenting Cells.
Signaling through the antigen receptors can be enhanced by signaling through the B-cell co-receptor on B cells or the CD4 and CD8 co-receptor molecules on T cells; signaling through the co-stimulatory receptor CD28 on T cells also contributes to activating naive T cells.
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These MHC molecules are membrane-bound surface receptors on antigen-presenting cells, like dendritic cells and macrophages. CD4 and CD8 play a role in T cell recognition and activation by binding to either MHCI or MHCII.
