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  1. Apr 13, 2022 · The two major classes of glycoproteins entrusted with antigen presentation are the MHC class I and class II molecules, which present antigenic peptides to CD8 + T cells and CD4 + T cells,...

  2. Jun 15, 2007 · During differentiation, apoptosis ensures that lymphocytes express functional antigen receptors and is essential for eliminating lymphocytes with dangerous self-reactive specificities.

    • J T Opferman
    • joseph.opferman@stjude.org
    • 2008
  3. Sep 8, 2022 · Activation of B cells as APCs occurs via two major pathways: (i) through the B-cell receptor (T-cell dependent), or (ii) through germline encoded PAMP receptors (T-cell independent). PAMP receptors for macromolecules like polysaccharides, lipopolysaccharides, and other non-protein antigens, have been shown to induce antigen presentation in B cells.

  4. Oct 15, 2016 · Cell signaling pathways regulate much in the life of a cell: from shuttling cargo through intracellular compartments and onto the cell surface, how it should respond to stress, protecting itself from harm (environmental insults or infections), to ultimately, death by apoptosis.

  5. Sep 14, 2023 · •. IgA + GC B cells receive increased T cell help and resist FasL-induced cell death. •. IgA BCR, not Fas-FasL axis, controls differentiation into gut-homing plasma cells. Summary. Immunoglobulin A (IgA) maintains commensal communities in the intestine while preventing dysbiosis.

  6. Sep 1, 2019 · Results from a gene microarray study showed that the onco-miRs, miR-19b and miR-20a, were differently expressed in patients with MM and normal controls. MiR19b/20a promotes cell proliferation and migration, and inhibits cell apoptosis by targeting PTEN in patients with MM .

  7. Oct 12, 2000 · This article focuses on death receptor-associated apoptosis and the role of CD95 (Apo-1/Fas)-mediated signalling in T-cell and B-cell development and during the course of an immune response.

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