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Uncoupler. An uncoupler or uncoupling agent is a molecule that disrupts oxidative phosphorylation in prokaryotes and mitochondria or photophosphorylation in chloroplasts and cyanobacteria by dissociating the reactions of ATP synthesis from the electron transport chain. The result is that the cell or mitochondrion expends energy to generate a ...
Any attempt to use uncouplers as a therapeutic will have to be carefully controlled because uncoupling the respiratory chain completely would be lethal. But there may be subtle ways to modulate the electron transport chain and keep mitochondria running “cleaner.”. Andrews reported, for example, that fatty acids (in this case palmitate) led ...
Another avenue of research has centered on the development of novel synthetic uncouplers that have more favorable safety profiles than DNP. These compounds aim to maintain the desired effects on energy expenditure and weight loss while minimizing the risk of hyperthermia and other adverse effects. Several new uncoupling agents have shown ...
Mitochondrial respiration and uncoupling. During cellular respiration, the oxidation of substrates such as glucose and fatty acids [] yields electrons (e −) in the form of reduced hydrogen carriers, NADH and FADH 2, which are donated to a series of enzyme complexes embedded in the inner mitochondrial membrane (IMM), ultimately reducing oxygen to water [].
UCP2 and UCP3 do not play a role in basal proton leak, but various stimuli can induce their activity, including sepsis. An increase in proton leak and mitochondrial uncoupling proteins have been reported during sepsis in several tissues, in both animal models [ 85 , 196–200 ] and patients [ 85 , 199 ], however literature specific to the heart is sparse.
Background. Mitochondrial uncouplers are well-known for their ability to treat a myriad of metabolic diseases, including obesity and fatty liver diseases. However, for many years now, mitochondrial uncouplers have also been evaluated in diverse models of cancer in vitro and in vivo. Furthermore, some mitochondrial uncouplers are now in clinical ...
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May 14, 2020 · Obesity is a global pandemic with limited treatment options. Here, the authors show evidence in mice that the mitochondrial uncoupler BAM15 effectively induces fat loss without affecting food ...
