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May 14, 2020 · Obesity is a health problem affecting more than 40% of US adults and 13% of the global population. Anti-obesity treatments including diet, exercise, surgery and pharmacotherapies have so far ...
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Mitochondrial respiration and uncoupling. During cellular respiration, the oxidation of substrates such as glucose and fatty acids [] yields electrons (e −) in the form of reduced hydrogen carriers, NADH and FADH 2, which are donated to a series of enzyme complexes embedded in the inner mitochondrial membrane (IMM), ultimately reducing oxygen to water [].
Background. Mitochondrial uncouplers are well-known for their ability to treat a myriad of metabolic diseases, including obesity and fatty liver diseases. However, for many years now, mitochondrial uncouplers have also been evaluated in diverse models of cancer in vitro and in vivo. Furthermore, some mitochondrial uncouplers are now in clinical ...
Background: Mitochondrial uncouplers shuttle protons across the inner mitochondrial membrane via a pathway that is independent of adenosine triphosphate (ATP) synthase, thereby uncoupling nutrient oxidation from ATP production and dissipating the proton gradient as heat. While initial toxicity concerns hindered their therapeutic development in the early 1930s, there has been increased interest ...
- Leigh Goedeke, Gerald I. Shulman
- 2021
Aug 8, 2021 · Abstract. There has been an explosion of interest in the use of uncouplers of oxidative phosphorylation in mitochondria in the treatment of several pathologies, including neurological ones. In this review, we analyzed all the mechanisms associated with mitochondrial uncoupling and the metabolic and signaling cascades triggered by uncouplers.
Dieters reported weight loss of up to 2 lb (0.9 kg) per week. 52 The chemical is now used in herbicides, dyes, wood preservatives, and explosives, but people still experiment with its weight-loss properties. 53–55 The hyperthermia associated with this drug can be severe, with core body temperatures as high as 42°C (108°F). 56–59 The treatment of patients with salicylate or dinitrophenol ...
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Jul 30, 2019 · Mitochondrial uncoupling can be caused by a va ri ety of conditions and molecules that exert an. influence not only on proton leak and cation cyclin g but also on proton slip within the proton ...
