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Jan 26, 2024 · Abstract The activity of many physiological mechanisms depends on pH; therefore, maintaining a normal pH in the body is one of the important tasks of homeostatic regulation. Shifts in the acid–base balance can be associated with both pathological and physiological processes. Physiological acidosis in skeletal muscles appears due to physical exercise as muscle contractions may significantly ...
Lactic acidosis is a common adverse finding in the critically ill patient. Physiological studies in preclinical animal models have long established that systemic acidemia can impair cardiovascular function, weakening cardiac contractility and reducing peripheral vascular reactivity to constrictor agonists . However, underlying mechanisms have ...
- Martin G. Frasch, Dino A. Giussani
- 2021
May 1, 2014 · The effects of acidosis on the cardiovascular system have been investigated, especially in left ventricular depressant dysfunction and systemic vasodilatation. 2, 4 Acidosis can also promote the development of severe ventricular arrhythmia after reperfusion for myocardial infarction. 5 However, the influence of acidosis on the efficacy of vasopressor agents is still debated, although severe ...
- Charles Vidal, Charles Vidal, Stanislas Grassin-Delyle, Philippe Devillier, Emmanuel Naline, Emmanue...
- 2014
This is termed the metabolic theory of blood flow regulation. Increases or decreases in metabolism lead to increases or decreases in the release of these vasodilator substances. These metabolic mechanisms ensure that the tissue is adequately supplied by oxygen and that products of metabolism (e.g., CO 2, H +, lactate) are removed.
Feb 21, 2024 · peripheral vasodilation by direct effect on vessels; acutely the acidosis will cause a right shift of the oxygen dissociation curve; if the acidosis persists, a decrease in red cell 2,3 DPG occurs which shifts the curve back to the left; CNS. cerebral vasodilation increasing cerebral blood flow and intracranial pressure
Extracellular acidosis dilates most arterial beds, but associated acid-base disturbances-e.g., intracellular acidification and decreases in HCO 3-concentration-can also elicit pro-contractile influences that diminish vasodilation and even dominate in some vascular beds to cause vasoconstriction. The ensemble activities of the acid-base-sensitive reactions in vascular smooth muscle and ...
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Mar 18, 2020 · Acidosis did not alter TAT, ARI dispersion or PTP (Figure 3 and Table 2). However, heart rate corrected ARI was significantly prolonged during the first 30 min of acidosis (from 163 ± 6.09 to 196 ± 5.52), lowered then during 60 and 90 min of acidosis to control levels and dropped significantly below control during reperfusion.
