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  1. Growth hormone (GH) is important for promotion of somatic growth and the regulation of substrate metabolism. Metabolic action of GH occurs in multiple tissues including the liver, muscle, fat and pancreas either directly or indirectly through insulin-like growth factor 1.

  2. Growth hormone (GH) is an anabolic hormone that has important functions in regulating somatic growth either directly or indirectly via effectors such as insulin-like growth factor-1 (IGF-1). However, another facet of the biological effects exerted by GH includes its ability to modulate metabolism and energy homeostasis.

  3. Abstract. Growth hormone (GH) and insulin-like growth factor-1 (IGF-I) are pleiotropic hormones with important roles in lifespan. They promote growth, anabolic actions, and body maintenance, and in conditions of energy deprivation, favor catabolic feedback mechanisms switching from carbohydrate oxidation to lipolysis, with the aim to preserve protein storages and survival.

  4. May 1, 2023 · A growth factor, as initially defined, is a secreted biologically active molecule that can affect the growth of cells. This definition has become expanded to include secreted molecules that promote or inhibit mitosis or affect cellular differentiation. Growth factors can act on specific cell surface receptors that subsequently transmit their growth signals to other intracellular components and ...

    • 2023/05/01
  5. May 1, 2023 · Human growth hormone (HGH), also known as somatotropin, is a 191 amino acid single-chain polypeptide produced by somatotropic cells within the anterior pituitary gland. As its name implies, scientists originally found it to be responsible for growth regulation during childhood. However, research has determined that HGH is also responsible for the regulation of many of the body’s other basal ...

    • Joshua E. Brinkman, Muhammad Ali Tariq, Logan Leavitt, Sandeep Sharma
    • 2023/05/01
    • 2020
  6. Insulin-like growth factor 1 is a major effector of growth hormone. IGF1 binds the IGF1 receptor with high affinity and the insulin receptor with lower affinity. IGF1 has actions distinct from ...

  7. Sep 1, 1997 · Blood samples were taken for Hb, PCV, red blood cell count (RBC), ferritin, vitamin B 12, red cell folate (RBC-folate), IGF-I, insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3), and erythropoietin (EPO). Twenty milliliters of heparinized blood were collected for blood volume assay.

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