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  1. www.cell.com › current-biology › fulltextMicrotubule dynamic instability: Current Biology - Cell Press

    Jul 25, 2006 · Dynamic instability allows microtubules to rapidly explore space. If microtubules are preferentially stabilized or destabilized when they reach certain locations, the cell can build microtubule arrays with specific shapes. For example, during mitosis, selective stabilization of microtubules that encounter chromosomes is thought to help form the ...

  2. www.frontiersin.org › journals › plant-scienceThe role of dynamic instability in microtubule organization

    Dynamic Instability of Microtubules. The co-existence of growing and shrinking microtubules in the same conditions is termed “dynamic instability.”. This phenomenon was first predicted based on observations of fixed in vitro reconstituted microtubules (Mitchison and Kirschner, 1984a, b).

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  4. www.nature.com › articles › s41580/021/00399-xRegulation of microtubule dynamics, mechanics and function ...

    Aug 18, 2021 · Microtubule dynamics and their control are essential for the normal function and division of all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic microtubule ...

    • Nikita B Gudimchuk, Nikita B Gudimchuk, J Richard McIntosh
    • 2021

  5. www.nature.com › articles › s41580/018/0009-yMicrotubule dynamics: an interplay of biochemistry and ...

    Apr 19, 2018 · Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular organization, organelle trafficking and chromosome segregation. Microtubule growth and shrinkage occur via ...

    • Gary J. Brouhard, Luke M. Rice
    • 2018

  6. www.cell.com › cell-systems › fulltextDynamic Instability from Non-equilibrium Structural ...

    Oct 20, 2020 · We present a structural mechanochemical model that explains all the phenomena of dynamic instability of microtubules, including growth, shortening, catastrophe, rescue, and pausing at both plus and minus ends. This model is based on the hypothesis that all these phenomena are driven by bent-to-straight-to-curved conformational changes of tubulins monomers and interfaces.

    • Shannon F. Stewman, Kenneth K. Tsui, Ao Ma
    • 2020

  7. www.cell.com › biophysj › fulltextDynamic instability from nonequilibrium structural ...

    Feb 10, 2023 · Microtubules are the backbone of the cytoskeleton and vital to numerous cellular processes. All the functions of microtubules are driven by dynamic instability, but its mechanism has remained unresolved for over 30 years because of conceptual difficulties inherent in the prevalent GTP-cap framework. We present a physically rigorous structural mechano-chemical model: dynamic instability is ...

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  9. pubmed.ncbi.nlm.nih.gov › 19754441Regulation of microtubule dynamic instability - PubMed

    Proper regulation of MT (microtubule) dynamics is essential for various vital processes, including the segregation of chromosomes, directional cell migration and differentiation. MT assembly and disassembly is modulated by a complex network of intracellular factors that co-operate or antagonize each other, are highly regulated in space and time ...