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- Bacteria actively modify their cell walls by editing PG components in response to environmental challenges. Diverse variations in peptide composition, cross-linking patterns, and glycan strand structures empower bacteria to resist antibiotics, evade host immune detection, and adapt to dynamic environments.
www.sciencedirect.com/org/science/article/pii/S1470875224001600Mechanisms conferring bacterial cell wall variability and ...
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Peptidoglycan is an essential component of the cell wall that protects bacteria from environmental stress. A carefully coordinated biosynthesis of peptidoglycan during cell elongation and division is required for cell viability.
Oct 13, 2020 · Biotic and abiotic stressors-including host defenses, cell wall active antibiotics, and predatory bacteria and phage-also jeopardize peptidoglycan integrity by introducing lesions, which must be rapidly repaired to prevent cell lysis. Here, we review recently discovered mechanisms that promote robust peptidoglycan synthesis during environmental ...
- Elizabeth A. Mueller, Petra Anne Levin
- 2020
Oct 13, 2020 · Several pieces of evidence implicate a role for the bifunctional class A PBPs, and specially PBP1b, in E. coli cell wall quality control. (i) Class A PBP dynamics suggest a unique role in cell wall synthesis compared to other PBPs (11, 95). (ii) PBP1b activity is elevated in response to cell envelope stress (95, 96).
Mar 1, 2023 · A study demonstrates that specific interactions between the two committed enzymes for the synthesis of lipopolysaccharide and peptidoglycan enable coordinated assembly of the outer membrane and...
Nov 12, 2016 · Scaffolds influence bacterial cell wall synthesis by controlling the spatial arrangement of PBPs and PG hydrolases, ensuring that the PG meshwork remains intact as the cell wall is remodelled and expanded during cycles of cell division and growth.
Peptidoglycan is an essential component of the cell wall that protects bacteria from environmental stress. A carefully coordinated biosynthesis of peptidoglycan during cell elongation and division is required for cell viability.
